{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:19:08Z","timestamp":1778642348722,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T00:00:00Z","timestamp":1338768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"Background and purpose<\/jats:title>Physical therapy is recommended for the treatment of H<\/jats:styled-content>untington's disease, but reliable studies investigating its efficacy are almost non\u2010existent. This may in part be due to the lack of suitable outcome measures. Therefore, we investigated the applicability of novel quantitative and objective assessments of motor dysfunction in the evaluation of physical therapy interventions aimed at improving gait and posture.<\/jats:p><\/jats:sec>Methods<\/jats:title>Twelve patients with H<\/jats:styled-content>untington disease received a predefined twice\u2010weekly intervention focusing on posture and gait over 6\u00a0weeks. The GAITR<\/jats:styled-content>ite mat and a force plate were used for objective and quantitative assessments. The U<\/jats:styled-content>nified H<\/jats:styled-content>untingtons D<\/jats:styled-content>isease R<\/jats:styled-content>ating S<\/jats:styled-content>cale T<\/jats:styled-content>otal M<\/jats:styled-content>otor S<\/jats:styled-content>core, the timed U<\/jats:styled-content>p &G<\/jats:styled-content>o test, and the B<\/jats:styled-content>erg B<\/jats:styled-content>alance S<\/jats:styled-content>cale were used as clinical outcome measures.<\/jats:p><\/jats:sec>Results<\/jats:title>Significant improvements were seen in GAITR<\/jats:styled-content>ite measures after therapy. Improvements were also seen in the U<\/jats:styled-content>p & G<\/jats:styled-content>o test and B<\/jats:styled-content>erg B<\/jats:styled-content>alance S<\/jats:styled-content>cale, whereas force plate measures and T<\/jats:styled-content>otal M<\/jats:styled-content>otor S<\/jats:styled-content>cores did not change.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The results suggest that physical therapy has a positive effect on gait in H<\/jats:styled-content>untington's disease. The study shows that objective and quantitative measures of gait and posture may serve as endpoints in trials assessing the efficacy of physical therapy. They should be explored further in larger trials applying a randomized controlled setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1331.2012.03760.x","type":"journal-article","created":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T19:16:22Z","timestamp":1338837382000},"page":"389-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Physical therapy in H<\/scp>untington's disease \u2013 toward objective assessments?"],"prefix":"10.1111","volume":"20","author":[{"given":"S.","family":"Bohlen","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospital Muenster University of Muenster Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ekwall","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Uppsala University Hospital Uppsala 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