{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:09:38Z","timestamp":1789391378845,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T00:00:00Z","timestamp":1338768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Buddhist Dalin Tzu Chi General Hospital","award":["DTCRD 1002-I-12"],"award-info":[{"award-number":["DTCRD 1002-I-12"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>To investigate the risk of stroke development following a diagnosis of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ell's palsy in a nationwide follow\u2010up study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>Information on <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ell's palsy and other factors relevant for stroke was obtained for 433\u00a0218 eligible subjects without previous stroke who had ambulatory visit in 2004. Of those, 897 patients with <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ell's palsy were identified. Over a median 2.9\u00a0years of follow\u2010up, 4581 incident strokes were identified. We estimated hazard ratios (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) and 95% confidence intervals [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] with <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ox proportional hazard models adjusting for age, sex, co\u2010morbidities, and important risk factors. Standardized incidence ratio of stroke amongst patients with <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ell's palsy was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with non\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ell's palsy patients, patients with <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ell's palsy had a 2.02\u2010times (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.42\u20132.86) higher risk of stroke. The adjusted <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> of developing stroke for patients with <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ell's palsy treated with and without systemic steroid were 1.67 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.69\u20134) and 2.10 (95%, 1.40\u20133.07), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ell's palsy carry a higher risk of stroke than the general population. Our data suggest that these patients might benefit from a more intensive stroke prevention therapy and regular follow\u2010up after initial diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1331.2012.03765.x","type":"journal-article","created":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T19:16:01Z","timestamp":1338837361000},"page":"616-622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Increased stroke risk in <scp>B<\/scp>ell's palsy patients without steroid treatment"],"prefix":"10.1111","volume":"20","author":[{"given":"C.\u2010C.","family":"Lee","sequence":"first","affiliation":[{"name":"Community Medicine Research Center and Institute of Public Health, National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Otolaryngology Buddhist Dalin Tzu Chi General Hospital Chiayi Taiwan"},{"name":"Cancer Center Buddhist Dalin Tzu Chi General Hospital Chiayi Taiwan"},{"name":"School of Medicine Tzu Chi University Hualian Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010C.","family":"Su","sequence":"additional","affiliation":[{"name":"Cancer Center Buddhist Dalin Tzu Chi General Hospital Chiayi Taiwan"},{"name":"School of Medicine Tzu Chi University Hualian Taiwan"},{"name":"Division of Hematology\u2010Oncology, Department of Internal Medicine Buddhist Dalin Tzu Chi General Hospital Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010H.","family":"Chien","sequence":"additional","affiliation":[{"name":"School of Medicine Tzu Chi University Hualian Taiwan"},{"name":"Division of Plastic Surgery, Department of Surgery Buddhist Dalin Tzu Chi General Hospital Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010C.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Buddhist Dalin Tzu Chi General Hospital Chiayi Taiwan"},{"name":"Cancer Center Buddhist Dalin Tzu Chi General Hospital Chiayi Taiwan"},{"name":"School of Medicine Tzu Chi University Hualian Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010K.","family":"Hung","sequence":"additional","affiliation":[{"name":"Cancer Center Buddhist Dalin Tzu Chi General Hospital Chiayi Taiwan"},{"name":"School of Medicine Tzu Chi University Hualian Taiwan"},{"name":"Department of Radiation Oncology Buddhist Dalin Tzu Chi General Hospital Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Cancer Center Buddhist Dalin Tzu Chi General Hospital Chiayi Taiwan"},{"name":"School of Medicine Tzu Chi University Hualian Taiwan"},{"name":"Department of Radiation Oncology Buddhist Dalin Tzu Chi General Hospital Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Chou","sequence":"additional","affiliation":[{"name":"Community Medicine Research Center and Institute of Public Health, National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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