{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:03:03Z","timestamp":1759564983648,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,6,30]],"date-time":"2012-06-30T00:00:00Z","timestamp":1341014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Western Norwegian regional Health authority","award":["911218"],"award-info":[{"award-number":["911218"]}]},{"name":"Norwegian Parkinson Disease Association","award":["0209"],"award-info":[{"award-number":["0209"]}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"crossref","award":["177966"],"award-info":[{"award-number":["177966"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"Background and objective<\/jats:title>Sleep problems are common in P<\/jats:styled-content>arkinson's disease (PD<\/jats:styled-content>) and increasingly so with disease progression. The frequency of these problems and the influence of dopaminergic treatment on sleep in early stages of PD<\/jats:styled-content> remain unclear. We have therefore in this study examined the subjective experience of sleep problems in drug\u2010na\u00efve patients with early PD<\/jats:styled-content> and how these problems developed after 1\u00a0year on dopaminergic treatment using the P<\/jats:styled-content>arkinson's D<\/jats:styled-content>isease S<\/jats:styled-content>leep S<\/jats:styled-content>cale (PDSS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>In all, 138 drug\u2010na\u00efve patients with early PD<\/jats:styled-content> derived from a population\u2010based incident cohort and 138 age\u2010 and gender\u2010matched control subjects were thoroughly assessed for Parkinsonism, cognition, depressive symptoms and sleep by structured interviews and clinical examination at the time of diagnosis and 1\u00a0year later on medication. Sleep problems were assessed using the PDSS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>The total PDSS<\/jats:styled-content> score for patients with PD<\/jats:styled-content> was lower compared with controls, 119 vs. 127 (P<\/jats:italic><\/jats:styled-content>\u00a0<\u00a00.05) at baseline and 121 vs. 128 (P<\/jats:italic><\/jats:styled-content>\u00a0<\u00a00.005) after 1\u00a0year on drugs. Analyses of PDSS<\/jats:styled-content> subdomains showed more nocturnal motor off symptoms both at baseline and after 1\u00a0year (P<\/jats:italic>\u00a0<\u00a00.005) and increased daytime somnolence in patients compared with control subjects (P<\/jats:italic><\/jats:styled-content>\u00a0<\u00a00.005 at baseline and P<\/jats:italic><\/jats:styled-content>\u00a0<\u00a00.05 after 1 year). Only minor changes in sleep scores were seen after the introduction of dopaminergic treatment.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Patients with early PD<\/jats:styled-content> report only modestly increased subjective sleep problems at the time of diagnosis compared with control subjects and dopaminergic treatment during the first year in general only slightly changed the experienced sleep problems.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1331.2012.03791.x","type":"journal-article","created":{"date-parts":[[2012,6,30]],"date-time":"2012-06-30T09:12:21Z","timestamp":1341047541000},"page":"1575-1581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Subjective sleep problems in patients with early Parkinson's disease"],"prefix":"10.1111","volume":"19","author":[{"given":"S.","family":"Stefansdottir","sequence":"first","affiliation":[{"name":"Department of Clinical Neurophysiology Stavanger University Hospital Stavanger Norway"},{"name":"Department of Neurology Stavanger University Hospital Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. D.","family":"Gjerstad","sequence":"additional","affiliation":[{"name":"Department of Neurology Stavanger University Hospital Stavanger Norway"},{"name":"Norwegian Centre for Movement Disorders Stavanger University Hospital Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. B.","family":"Tysnes","sequence":"additional","affiliation":[{"name":"Department of Neurology Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Movement Disorders Stavanger University Hospital Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2010.02.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.05.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10193"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2004.00971.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(09)70845-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.168211"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.1.33"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_2_7_12_1","first-page":"153","volume-title":"Recent developments in Parkinson's disease","author":"Fahn S","year":"1987"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.6.629"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70476-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.2.388"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2006.08.003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.6.793"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20874"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(09)70792-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.10.1544"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2005.02.006"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2009.02.012"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-1331.2012.03791.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-1331.2012.03791.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T11:21:48Z","timestamp":1698664908000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-1331.2012.03791.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,30]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/j.1468-1331.2012.03791.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-1331.2012.03791.x","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"type":"print","value":"1351-5101"},{"type":"electronic","value":"1468-1331"}],"subject":[],"published":{"date-parts":[[2012,6,30]]},"assertion":[{"value":"2012-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-05-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}