{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:42:08Z","timestamp":1783035728440,"version":"3.54.6"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,8,10]],"date-time":"2012-08-10T00:00:00Z","timestamp":1344556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"Background<\/jats:title>An increase in late\u2010onset myasthenia gravis (MG<\/jats:styled-content>) has been reported. There are few large population\u2010based studies over longer periods of time reflecting recent developments in MG<\/jats:styled-content> incidence.<\/jats:p><\/jats:sec>Methods<\/jats:title>We identified a nationwide cohort of patients with incident myasthenia in D<\/jats:styled-content>enmark in 1996\u20132009. We used a validated algorithm to track subjects based on a combination of diagnosis and prescription (pyridostigmine) data from nationwide registers. Patients with myasthenia were classified into early onset (<50\u00a0years old) and late onset (50+ years). We calculated incidence rates (IR<\/jats:styled-content>s) and corresponding 95% confidence intervals.<\/jats:p><\/jats:sec>Results<\/jats:title>We identified 693 patients (362 women) with incident MG<\/jats:styled-content> in the study period corresponding to an IR<\/jats:styled-content> of 9.2 per million person\u2010years (8.5\u20139.9). Overall, 207 (29.9%) were classified as early\u2010onset and 486 (70.1%) as late\u2010onset MG<\/jats:styled-content>. Women predominated in the early\u2010onset group (70.5%), but not in the late\u2010onset group (44.4%). The incidence rate of early\u2010onset MG<\/jats:styled-content> was 4.2 (3.6\u20134.8) and late\u2010onset MG<\/jats:styled-content> 18.9 (17.3\u201320.7) per million person\u2010years and it did not vary over time in the study period (P<\/jats:italic>\u2010values for trend 0.54 and 0.15, respectively).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Late\u2010onset MG<\/jats:styled-content> comprised a large proportion of all incident cases in D<\/jats:styled-content>enmark, was more common in men than women, and occurred with a stable incidence in the 14\u2010year study period. Therefore, we speculate whether previous reports of a rise in late\u2010onset MG<\/jats:styled-content> reflect a non\u2010biological phenomenon, that is, a gradual improvement in the diagnosis of MG<\/jats:styled-content> in this age group in previous years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1331.2012.03850.x","type":"journal-article","created":{"date-parts":[[2012,8,10]],"date-time":"2012-08-10T08:54:21Z","timestamp":1344588861000},"page":"309-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Late\u2010onset myasthenia not on the increase: a nationwide register study in D<\/scp>enmark, 1996\u20132009"],"prefix":"10.1111","volume":"20","author":[{"given":"E. G.","family":"Pedersen","sequence":"first","affiliation":[{"name":"Department of Neurology Odense University Hospital Odense Denmark"},{"name":"Institute of Clinical Research Faculty of Health Sciences University of Southern Denmark (SDU) Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hallas","sequence":"additional","affiliation":[{"name":"Institute of Public Health Clinical Pharmacology Unit SDU Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. E. H.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Neuroimmunology Laboratory DMSC Department of Neurology, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Gaist","sequence":"additional","affiliation":[{"name":"Department of Neurology Odense University Hospital Odense Denmark"},{"name":"Institute of Clinical Research Faculty of Health Sciences University of Southern Denmark (SDU) Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70063-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000050461.05432.C5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.44.572"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000176067.32186.a3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318217e735"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5651-z"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.8.1105"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331481"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"key":"e_1_2_7_12_1","volume-title":"Anatomical Therapeutic Chemical (ATC) Classification Index with Defined Daily Doses (DDDs)","author":"WHO Collaborating Centre for Drug Statistics Methodology","year":"2000"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6632.1313"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.152637"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-10-46"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23271"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb51317.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-156-7"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-1331.2012.03850.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-1331.2012.03850.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T09:48:59Z","timestamp":1700646539000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-1331.2012.03850.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,10]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/j.1468-1331.2012.03850.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-1331.2012.03850.x","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,10]]},"assertion":[{"value":"2012-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-08-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}