{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T08:50:29Z","timestamp":1772527829477,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T00:00:00Z","timestamp":1349654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Essential tremor is an abnormal movement characterized by postural and\/or kinetic tremor. In some essential tremor patients, rest tremor (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>) is observed but it is not clear if this <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> is a feature of essential tremor or a symptom of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>arkinson's disease (PD). <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>123\u2010<jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CIT<\/jats:styled-content> single\u2010photon emission tomography is used to distinguish essential tremor and <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyse <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>123\u2010<jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CIT<\/jats:styled-content> single\u2010photon emission tomography in a larger series of patients with mixed tremor (i.e. action tremor associated with <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>) without <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 33 consecutives patients (18 men and 15 women) with mixed tremor, clinically and by neuroimaging in all cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>123\u2010<jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CIT<\/jats:styled-content> single\u2010photon emission tomography was abnormal in 25 of our patients (75.7%) with mixed tremor, and we noted a reduced uptake mostly in the putamen. In our patients with abnormal imaging, <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> was unilateral in 52%.<\/jats:p><jats:p>In 15 of these 25 patients, putaminal reduced uptake was bilateral and symmetrical. In the other 10 patients, putaminal reduced uptake was asymmetrical or unilateral. In these 10 cases, six had a unilateral <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> corresponding to (crossed) predominant reduced uptake in three cases. In our patients with normal imaging, <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> was unilateral in 87.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study shows that mixed tremor is a heterogeneous entity. The majority of patients with mixed tremor showed nigrostriatal dysfunction on <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>123\u2010<jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CIT<\/jats:styled-content> single\u2010photon emission tomography, suggesting that mixed tremor may be a parkinsonian syndrome rather than a clinical variant of essential tremor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1331.2012.03875.x","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T03:56:20Z","timestamp":1349754980000},"page":"382-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["I123\u2010<scp>FP<\/scp>\u2010<scp>CIT<\/scp> single\u2010photon emission tomography in patients with long\u2010standing mixed tremor"],"prefix":"10.1111","volume":"20","author":[{"given":"M.","family":"de Verdal","sequence":"first","affiliation":[{"name":"Department of Neurology CHU Caremeau Nimes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Renard","sequence":"additional","affiliation":[{"name":"Department of Neurology CHU Caremeau Nimes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Collombier","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine CHU Caremeau Nimes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Boudousq","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine CHU Caremeau Nimes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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