{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:19:26Z","timestamp":1792653566402,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T00:00:00Z","timestamp":1349913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Clinical stroke trials with stem cell\u2010based approaches aiming for trophic actions, modulation of inflammation and neuroprotection are ongoing. However, experimental studies also suggest that neuronal replacement by grafted neural stem cells (<jats:styled-content style=\"fixed-case\">NSC<\/jats:styled-content>s) and possibly by endogenous<jats:styled-content style=\"fixed-case\">NSC<\/jats:styled-content>s from the subventricular zone (<jats:styled-content style=\"fixed-case\">SVZ<\/jats:styled-content>) may restore function in the stroke\u2010damaged striatum. To evaluate the potential clinical impact of these findings, we analyzed the spatial relationship of infarcts to the<jats:styled-content style=\"fixed-case\">SVZ<\/jats:styled-content>and the proportion of individuals with striatal lesions in a consecutive series of ischaemic stroke patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients aged 20\u201375\u00a0years with first\u2010ever ischaemic stroke underwent<jats:styled-content style=\"fixed-case\">DW<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>of the brain within 4\u00a0days after stroke onset. We analyzed location, size, number of acute focal ischaemic abnormalities and their spatial relationship to the<jats:styled-content style=\"fixed-case\">SVZ<\/jats:styled-content>. Stroke severity was assessed using<jats:styled-content style=\"fixed-case\">NIH<\/jats:styled-content>Stroke Scale (<jats:styled-content style=\"fixed-case\">NIHSS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 108 included patients, the distance from the nearest margin of the infarct(s) to the<jats:styled-content style=\"fixed-case\">SVZ<\/jats:styled-content>was \u22642\u00a0mm in 51\/102 patients with visible ischaemic lesions on<jats:styled-content style=\"fixed-case\">DW<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. Twenty\u2010four patients had involvement of striatum. Eight of these had predominantly striatal lesions, that is &gt;50% of the total ischaemic lesion volume was located in caudate nucleus and\/or putamen. These 8 patients had a median<jats:styled-content style=\"fixed-case\">NIHSS<\/jats:styled-content>of 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Many stroke patients have infarcts located close to the<jats:styled-content style=\"fixed-case\">SVZ<\/jats:styled-content>, providing some supportive evidence that optimized endogenous neurogenesis may have therapeutic potential. However, predominantly striatal infarcts are rare and tend to give mild neurological deficits, indicating that striatum should not be the primary target for neuronal replacement efforts in humans.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1331.2012.03877.x","type":"journal-article","created":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T15:21:33Z","timestamp":1349968893000},"page":"473-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Proximity of brain infarcts to regions of endogenous neurogenesis and involvement of striatum in ischaemic stroke"],"prefix":"10.1111","volume":"20","author":[{"given":"H.","family":"Delavaran","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund Lund University Lund Sweden"},{"name":"Department of Neurology Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Sjunnesson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Lund University Lund Sweden"},{"name":"Department of Neuroradiology Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Arvidsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Lund University Lund Sweden"},{"name":"Department of Neurology Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Lindvall","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Lund University Lund Sweden"},{"name":"Department of Neurology Sk\u00e5ne University Hospital Lund Sweden"},{"name":"Lund Stem Cell Center Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Norrving","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Lund University Lund Sweden"},{"name":"Department of Neurology Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"van Westen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Lund University Lund Sweden"},{"name":"Department of Neuroradiology Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Kokaia","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Lund University Lund Sweden"},{"name":"Department of Neurology Sk\u00e5ne University Hospital Lund Sweden"},{"name":"Lund Stem Cell Center Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lindgren","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Lund University Lund Sweden"},{"name":"Department of Neurology Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.599654"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70061-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000976"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1981.6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21066"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808488105"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000247888.25985.62"},{"key":"e_1_2_7_9_1","first-page":"549","volume-title":"Adult Neurogenesis","author":"Lindvall O","year":"2008"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000154107"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm747"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10393"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0281"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603512103"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cbccec"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90084-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.7.864"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20798"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.12.1730"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.3.688"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/oso\/9780192631572.003.0003","volume-title":"Subcortical Stroke","author":"Donnan G","year":"2002"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.510982"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07287"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.3.674"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.046383"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-1331.2012.03877.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-1331.2012.03877.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/j.1468-1331.2012.03877.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-1331.2012.03877.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T06:17:32Z","timestamp":1714457852000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-1331.2012.03877.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,11]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/j.1468-1331.2012.03877.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-1331.2012.03877.x","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,11]]},"assertion":[{"value":"2012-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-08-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}