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Originally, non\u2010lamellar\u2010forming ingredients were used such as petrolatum but recent research has shown the advantage of using lamellar\u2010forming ingredients such as ceramides, pseudoceramides and phospholipids in the relief of dry skin. Nevertheless, the importance of using lipid\u2010phase transition inducers, such as long\u2010chain fatty acids, has not been studied clinically. The evaluation of a novel complex of lipophilic ingredients was of interest: cetyl alcohol, isostearyl isostearate, potassium cetyl phosphate, cetyl behenate and behenic acid. The combination of all these ingredients was shown to be more effective than any single component in water vapour transmission rate studies. This was thought to be owing to the formation of a unique structural organization of the lipids upon dry\u2010down from an <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content> emulsion as was examined by <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010ray diffraction and optical microscopy. When evaluated clinically in a randomized double\u2010blind and vehicle\u2010controlled moisturization efficacy trial, this novel blend of ingredients was shown to not only improve the visible signs of skin dryness to a significantly greater extent than a comparable mineral oil\u2010containing vehicle but also then maintain a better skin condition during the regression no\u2010treatment phase of the study. This combination of ingredients offers a new technology option for the treatment of dry skin.<\/jats:p>","DOI":"10.1111\/j.1468-2494.2012.00749.x","type":"journal-article","created":{"date-parts":[[2012,8,8]],"date-time":"2012-08-08T12:11:27Z","timestamp":1344427887000},"page":"567-574","source":"Crossref","is-referenced-by-count":14,"title":["The effect of an amphiphilic self\u2010assembled lipid lamellar phase on the relief of dry skin"],"prefix":"10.1111","volume":"34","author":[{"given":"G.","family":"Pennick","sequence":"first","affiliation":[{"name":"Croda Consumer Care Europe Goole U.K"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Chavan","sequence":"additional","affiliation":[{"name":"Croda Consumer Care Europe Goole U.K"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Summers","sequence":"additional","affiliation":[{"name":"Photobiology Laboratory Medunsa Campus Medunsa South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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