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The present study addresses the impact of ATP on neck muscle nociception in anaesthetized mice. Craniofacial nociceptive processing was tested by the jaw-opening reflex via noxious electrical tongue stimulation. Within 2 h after injection of 100 nmol\/l or 1 \u03bcmol\/l ATP into semispinal neck muscles, reflex integrals significantly increased by 114% or 328%, respectively. Preceding intramuscular administration of the P2X receptor antagonist PPADS (3\u2013100 nmol\/l) suppressed the ATP effect. Subsequent application of PPADS (100 nmol\/l) caused a total recovery of facilitated reflex to baseline values. ATP induces sustained facilitation of craniofacial nociception by prolonged excitation of P2X receptors in neck muscles.<\/jats:p>","DOI":"10.1111\/j.1468-2982.2006.01095.x","type":"journal-article","created":{"date-parts":[[2006,3,17]],"date-time":"2006-03-17T05:42:30Z","timestamp":1142574150000},"page":"697-706","source":"Crossref","is-referenced-by-count":27,"title":["ATP Induces Sustained Facilitation of Craniofacial Nociception Through p2x Receptors on Neck Muscle Nociceptors in Mice"],"prefix":"10.1177","volume":"26","author":[{"given":"A","family":"Makowska","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Experimental Neurosurgery Section, Medical Faculty, RWTH Aachen University, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Panfil","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Experimental Neurosurgery Section, Medical Faculty, RWTH Aachen University, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Ellrich","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Experimental Neurosurgery Section, Medical Faculty, RWTH Aachen University, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2006,6,1]]},"reference":[{"key":"bibr1-j.1468-2982.2006.01095.x","doi-asserted-by":"publisher","DOI":"10.1177\/033310240102100708"},{"key":"bibr2-j.1468-2982.2006.01095.x","unstructured":"Headache Classification Subcommittee of the International Headache Society. 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