{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:34:24Z","timestamp":1793914464941,"version":"4.8.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p>The aim of this study was to compare the effectiveness of strong advice to withdraw the overused medication with the effectiveness of two structured pharmacological detoxification strategies in a cohort of patients diagnosed with probable migraine overuse headache (MOH) plus migraine and presenting low medical needs. One hundred and twenty patients participated in the study. Exclusion criteria included: previous detoxification treatments, coexistent medical or psychiatric illnesses and overuse of agents containing opioids, benzodiazepines and barbiturates. Group A received only intensive advice to withdraw the overused medication. Group B underwent a standard out-patient detoxification programme (advice + prednisone + preventive treatment). Group C underwent a standard inpatient withdrawal programme (as in group B + fluid replacement and antiemetics). Withdrawal therapy was considered successful if, after 2 months, the patient had reverted to an episodic pattern of headache and to an intake of symptomatic medication on fewer than 10 days\/month. We were able to detoxify 75.4\u00b1 of the whole cohort, 77.5\u00b1 of patients in group A, 71.7\u00b1 of patients in group B and 76.9\u00b1 of those in group C ( P &gt; 0.05). In patients with migraine plus MOH and low medical needs, effective drug withdrawal may be obtained through the imparting of advice alone.<\/jats:p>","DOI":"10.1111\/j.1468-2982.2006.01175.x","type":"journal-article","created":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T05:18:06Z","timestamp":1153199886000},"page":"1097-1105","source":"Crossref","is-referenced-by-count":134,"title":["Advice Alone Vs. Structured Detoxification Programmes for Medication Overuse Headache: A Prospective, Randomized, Open-Label Trial in Transformed Migraine Patients With Low Medical Needs"],"prefix":"10.1177","volume":"26","author":[{"given":"P","family":"Rossi","sequence":"first","affiliation":[{"name":"Headache Clinic, INI Grottaferrata, Grottaferrata"},{"name":"IRCCS \u2018C. Mondino Institute of Neurology\u2019 Foundation, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Di","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Headache Clinic, INI Grottaferrata, Grottaferrata"},{"name":"Department of Clinical Neurology and Otolaryngology, University of Rome \u2018La Sapienza\u2019, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Faroni","sequence":"additional","affiliation":[{"name":"Headache Clinic, INI Grottaferrata, Grottaferrata"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Cesarino","sequence":"additional","affiliation":[{"name":"Headache Clinic, INI Grottaferrata, Grottaferrata"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Nappi","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurology and Otolaryngology, University of Rome \u2018La Sapienza\u2019, Rome"},{"name":"IRCCS \u2018C. Mondino Institute of Neurology\u2019 Foundation, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2006,9,1]]},"reference":[{"key":"bibr1-j.1468-2982.2006.01175.x","unstructured":"1 Headache Classification Committee of The International Headache Society. The International Classification of Headache Disorders, 2nd edition. Cephalalgia 2004;24:1\u2013160."},{"key":"bibr2-j.1468-2982.2006.01175.x","first-page":"247","volume-title":"Wolff's headache and other head pain","author":"Silberstein SD","year":"2001"},{"key":"bibr3-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2004.04128.x"},{"key":"bibr4-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00824-5"},{"key":"bibr5-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200406000-00011"},{"key":"bibr6-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1007\/s101940300020"},{"key":"bibr7-j.1468-2982.2006.01175.x","first-page":"871","volume-title":"The headaches","author":"Diener HC","year":"1999","edition":"2"},{"key":"bibr8-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1345\/aph.18184"},{"key":"bibr9-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2000.00099.x"},{"key":"bibr10-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-001-0061-7"},{"key":"bibr11-j.1468-2982.2006.01175.x","first-page":"1221","volume":"157","author":"Taimi C","year":"2001","journal-title":"Rev Neurol"},{"key":"bibr12-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464220-00002"},{"key":"bibr13-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1007\/s100720300059"},{"key":"bibr14-j.1468-2982.2006.01175.x","first-page":"89","volume-title":"Migraine: current concepts.","author":"Nappi G","year":"2004"},{"key":"bibr15-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1991.hed3102071.x"},{"key":"bibr16-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2000.00028.x"},{"key":"bibr17-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1991.hed3104205.x"},{"key":"bibr18-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.7.995"},{"key":"bibr19-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1007\/s004820050185"},{"key":"bibr20-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2001.00231.x"},{"key":"bibr21-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.1.4.331"},{"key":"bibr22-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2005.4501004.x"},{"key":"bibr23-j.1468-2982.2006.01175.x","doi-asserted-by":"crossref","first-page":"ii2","DOI":"10.1136\/jnnp.72.3.297","volume":"72","author":"Goadsby PJ","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"bibr24-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1069197"},{"key":"bibr25-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7436.397"},{"key":"bibr26-j.1468-2982.2006.01175.x","unstructured":"26 Silagy C, Stead LE. Physician advice for smoking cessation. Cochrane Database Syst Rev (2) CD000166. 2003."},{"key":"bibr27-j.1468-2982.2006.01175.x","doi-asserted-by":"crossref","unstructured":"27 Silberstein SD, Olesen J, Bousser MG, Diener HC, Dodick D, First M  The International Classification of Headache Disorders 2nd Edition (ICHD-II)\u2014revision of criteria for. 8.2 Medication Overuse Headache. Cephalalgia 2005; 25:460\u20135.","DOI":"10.1111\/j.1468-2982.2005.00878.x"},{"key":"bibr28-j.1468-2982.2006.01175.x","volume-title":"SCID-I CV","author":"Mazza F","year":"2000"},{"key":"bibr29-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2001.041007685.x"},{"key":"bibr30-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2003.00648.x"},{"key":"bibr31-j.1468-2982.2006.01175.x","first-page":"335","volume":"33","author":"Kudrow L.","year":"1982","journal-title":"Adv Neurol"},{"key":"bibr32-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1990.hed3010634.x"},{"key":"bibr33-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2001.00288.x"},{"key":"bibr34-j.1468-2982.2006.01175.x","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.1999.1901044.x"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1111\/j.1468-2982.2006.01175.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1111\/j.1468-2982.2006.01175.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1111\/j.1468-2982.2006.01175.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:42:14Z","timestamp":1777387334000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1111\/j.1468-2982.2006.01175.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1468-2982.2006.01175.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-2982.2006.01175.x","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}