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Migraine sufferers reported more intense nausea, headache, glare- and light-induced pain than controls. In addition, glare- and light-induced pain were greater in the tryptophan depletion condition than in the balanced amino acid condition, in both migraine sufferers and controls. Eight hours after the amino acid drink, after participants had completed tests of pain sensitivity and motion sickness provocation, tryptophan depletion augmented headache in migraine sufferers and aggravated nausea in migraine sufferers and controls. These findings suggest that a reduction in brain synthesis of serotonin intensifies photophobia and other migrainous symptoms and thus might contribute to the pathogenesis of migraine.<\/jats:p>","DOI":"10.1111\/j.1468-2982.2006.01212.x","type":"journal-article","created":{"date-parts":[[2006,9,8]],"date-time":"2006-09-08T15:20:45Z","timestamp":1157728845000},"page":"1225-1233","source":"Crossref","is-referenced-by-count":62,"title":["Tryptophan Depletion Increases Nausea, Headache and Photophobia in Migraine Sufferers"],"prefix":"10.1177","volume":"26","author":[{"given":"PD","family":"Drummond","sequence":"first","affiliation":[{"name":"School of Psychology, Murdoch University, Perth, Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2006,10,1]]},"reference":[{"key":"bibr1-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1972.hed1202069.x"},{"key":"bibr2-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1993.1303151.x"},{"key":"bibr3-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1997.1701003.x"},{"key":"bibr4-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.7.1473"},{"key":"bibr5-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2003.00571.x"},{"key":"bibr6-j.1468-2982.2006.01212.x","first-page":"275","volume-title":"The headaches","author":"Hamel E","year":"2006","edition":"3"},{"key":"bibr7-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-827175"},{"key":"bibr8-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1988.83"},{"key":"bibr9-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.32.6.555"},{"key":"bibr10-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1967.00470230096013"},{"key":"bibr11-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810170011002"},{"key":"bibr12-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(00)00161-5"},{"key":"bibr13-j.1468-2982.2006.01212.x","first-page":"R991","volume":"272","author":"Stancampiano R","year":"1997","journal-title":"Am J Physiol"},{"key":"bibr14-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1632-6"},{"key":"bibr15-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.10.5308"},{"key":"bibr16-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(97)00198-X"},{"key":"bibr17-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.721641.x"},{"key":"bibr18-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172339.15577.a6"},{"key":"bibr19-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1986.hed2609465.x"},{"key":"bibr20-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.10.1857"},{"key":"bibr21-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1997.3708492.x"},{"key":"bibr22-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520460125024"},{"key":"bibr23-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2001.111006031.x"},{"key":"bibr24-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1997.1707733.x"},{"key":"bibr25-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1993.1306417.x"},{"key":"bibr26-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1993.1305321.x"},{"key":"bibr27-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1934.00830160084010"},{"key":"bibr28-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-200203000-00002"},{"key":"bibr29-j.1468-2982.2006.01212.x","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-200203000-00001"},{"key":"bibr30-j.1468-2982.2006.01212.x","unstructured":"Walsh FB, Hoyt WF. 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