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We describe four previously asymptomatic paediatric patients with atrial septal defect who underwent percutaneous Amplatzer septal occluder device implantation and who subsequently developed symptoms compatible with migraine headache. The cases had normal echocardiograms after the intervention and a benign course with headache improvement after several weeks or months. There are paediatric patients with atrial septal defect who may dramatically develop migraine symptoms with or without aura following percutaneous correction of their defect. Large paediatric studies are needed to offer accurate prognoses for children and their families. The possibility of using clopidogrel to treat this type of headache is subject to debate.<\/jats:p>","DOI":"10.1111\/j.1468-2982.2007.01331.x","type":"journal-article","created":{"date-parts":[[2007,5,6]],"date-time":"2007-05-06T12:38:01Z","timestamp":1178455081000},"page":"550-556","source":"Crossref","is-referenced-by-count":14,"title":["Migraine Symptoms Related to the Percutaneous Closure of An Ostium Secundum Atrial Septal Defect: Report of Four Paediatric Cases and Review of the Literature"],"prefix":"10.1177","volume":"27","author":[{"given":"DM","family":"Fern\u00e1ndez-Mayoralas","sequence":"first","affiliation":[{"name":"Neuropaediatrics Section"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Fern\u00e1ndez-Ja\u00e9n","sequence":"additional","affiliation":[{"name":"Neuropaediatrics Section"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Mu\u00f1oz-Jare\u00f1o","sequence":"additional","affiliation":[{"name":"Neuropaediatrics Section"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Guti\u00e9rrez-Larraya","sequence":"additional","affiliation":[{"name":"Paediatric Cardiology Section of the Hospital de la Zarzuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Calleja-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Neuropaediatrics Section"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V San Antonio","family":"Arce","sequence":"additional","affiliation":[{"name":"Neuropaediatrics Section of the Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,6,1]]},"reference":[{"key":"bibr1-j.1468-2982.2007.01331.x","doi-asserted-by":"publisher","DOI":"10.1016\/S1695-4033(02)77961-7"},{"key":"bibr2-j.1468-2982.2007.01331.x","unstructured":"2 Headache Classification Committee of the International Headache Society. 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