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We performed mutation analysis in the CACNA1A gene in a monozygotic twin pair with clinical features overlapping with both AHC and FHM and identified a novel de novo CACNA1A mutation. We provide the first evidence that a CACNA1A mutation can cause atypical AHC, indicating an overlap of molecular mechanisms causing AHC and FHM. These results also suggest that CACNA1A mutation scanning is indicated in patients with a severe neurological phenotype that includes paroxysmal (alternating) hemiplegia.<\/jats:p>","DOI":"10.1111\/j.1468-2982.2008.01596.x","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T16:11:48Z","timestamp":1211386308000},"page":"887-891","source":"Crossref","is-referenced-by-count":58,"title":["<i>CACNA1A<\/i>\n                    Mutation Linking Hemiplegic Migraine and Alternating Hemiplegia of Childhood"],"prefix":"10.1177","volume":"28","author":[{"given":"B","family":"de Vries","sequence":"first","affiliation":[{"name":"Department of Human Genetics, Leiden University Medical Centre, Leiden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AH","family":"Stam","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Centre, 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