{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:07:01Z","timestamp":1777489621877,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p>The aim was to to determine if the visual aura of migraine is altered by disease of the afferent visual pathways and if visual aura changes are associated with pre- or postgeniculate lesions. Functional neuroimaging during migraine demonstrates primary visual\/extrastriate cortex as an anatomical substrate of visual aura. Neuro-ophthalmological records (including kinetic and static perimetry) of 25 patients with visual loss and typical aura with or without migraine headache were reviewed. Twenty-five patients (16 women, nine men) (mean age 59.8 years) with typical aura had visual loss from pregeniculate (72%) or postgeniculate lesions (28%). Eight patients (four postgeniculate cerebrovascular accidents or arteriovenous malformations, two lifelong optic neuropathy\/ retinopathy, one childhood ocular trauma, one anisometropic amblyopia) reported absence or alteration of visual aura. Postgeniculate lesions were significantly associated ( P = 0.017) with visual aura changes. The association of postgeniculate lesions with altered auras points to a postgeniculate effect on aura appearance (consistent with functional neuroimaging findings). Although statistically significant, this series' association of postgeniculate disease and aura changes is even more robust ( P = 0.0002) when structural changes of ocular dominance columns are posited in three patients with optic neuropathy, retinopathy and keratopathy of congenital or childhood origin.<\/jats:p>","DOI":"10.1111\/j.1468-2982.2008.01751.x","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T09:26:46Z","timestamp":1228987606000},"page":"430-435","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Visual Pathway Lesions on the Visual Aura of Migraine"],"prefix":"10.1177","volume":"29","author":[{"given":"FE","family":"Lepore","sequence":"first","affiliation":[{"name":"Departments of Neurology and Ophthalmology, UMDNJ\/Robert Wood Johnson Medical School, New Brunswick, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,4,1]]},"reference":[{"key":"bibr1-j.1468-2982.2008.01751.x","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1941.02280200137007"},{"key":"bibr2-j.1468-2982.2008.01751.x","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1981.00510070100024"},{"key":"bibr3-j.1468-2982.2008.01751.x","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/107.2.447"},{"key":"bibr4-j.1468-2982.2008.01751.x","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071582498"},{"key":"bibr5-j.1468-2982.2008.01751.x","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1293"},{"key":"bibr6-j.1468-2982.2008.01751.x","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.3_Part_1.444"},{"issue":"1","key":"bibr7-j.1468-2982.2008.01751.x","first-page":"9","volume":"24","author":"Headache Classification Subcommittee of the International Headache Society","year":"2004","journal-title":"Cephalalgia"},{"key":"bibr8-j.1468-2982.2008.01751.x","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-4182(06)80027-X"},{"key":"bibr9-j.1468-2982.2008.01751.x","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(58)90073-7"},{"key":"bibr10-j.1468-2982.2008.01751.x","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0571-88"},{"key":"bibr11-j.1468-2982.2008.01751.x","unstructured":"11 Penfield W, Rasmussen T. The cerebral cortex of man. New York: Macmillan 1955:145."},{"key":"bibr12-j.1468-2982.2008.01751.x","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/58.1.115"},{"issue":"1","key":"bibr13-j.1468-2982.2008.01751.x","first-page":"558","volume":"47","author":"Moskowitz MA","year":"2007","journal-title":"Headache"},{"key":"bibr14-j.1468-2982.2008.01751.x","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(78)80016-1"},{"key":"bibr15-j.1468-2982.2008.01751.x","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(94)00187-Q"},{"key":"bibr16-j.1468-2982.2008.01751.x","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e31814a6107"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1111\/j.1468-2982.2008.01751.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1111\/j.1468-2982.2008.01751.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1111\/j.1468-2982.2008.01751.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:44:04Z","timestamp":1777387444000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1111\/j.1468-2982.2008.01751.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1111\/j.1468-2982.2008.01751.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-2982.2008.01751.x","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}