{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:42:54Z","timestamp":1780472574703,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,4,15]],"date-time":"2004-04-15T00:00:00Z","timestamp":1081987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Erythrocyte sedimentation rate (ESR), C\u2010reactive protein (CRP) and cytokines, including serum interleukin (IL)\u20106, IL\u20108 and IL\u201010, and tumour necrosis factor\u2010alpha (TNF\u2010\u03b1) have been proposed as disease activity markers in Beh\u00e7et's disease (BD), although studies have shown conflicting results for IL\u20106. Serum procalcitonin (PCT) levels in active BD have not yet been investigated.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> The aim of the present study was to determine the reliability of serum IL\u20106 and PCT levels as well as CRP as biological markers for activity of BD.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Serum PCT, IL\u20106 and CRP protein levels were measured in patients with active BD (<jats:italic>n<\/jats:italic>\u00a0=\u00a015) and in healthy control subjects (<jats:italic>n<\/jats:italic>\u00a0=\u00a015). IL\u20106 and PCT levels were measured in serum by chemiluminescent assay. In addition, a nephelometric method was used to analyse CRP concentrations in serum.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Serum CRP and IL\u20106 values were significantly higher in the subjects with active disease than in the healthy controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), but there was no significant difference in the levels of PCT in the two groups.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The results of our study suggest that serum CRP and IL\u20106 levels are elevated in patients with active BD, but that serum PCT values are not elevated in these patients.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2004.00907.x","type":"journal-article","created":{"date-parts":[[2004,4,15]],"date-time":"2004-04-15T14:09:45Z","timestamp":1082038185000},"page":"318-320","source":"Crossref","is-referenced-by-count":64,"title":["Serum interleukin\u20106, procalcitonin and C\u2010reactive protein levels in subjects with active Beh\u00e7et's disease"],"prefix":"10.1111","volume":"18","author":[{"given":"B","family":"Adam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Calikoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,4,15]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"1152","article-title":"\u00dcber rezidivierende Aphtoese, durch ein Virus verursachte Geschw\u00fcre am Mund, am Auge und an den Genitalien","volume":"105","author":"Beh\u00e7et H","year":"1937","journal-title":"Dermatol Wochenschr"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1994.tb00063.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(99)00063-2"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70523-2"},{"key":"e_1_2_5_6_2","first-page":"1107","article-title":"TNF, soluble IL\u20102R and soluble CD8 in Beh\u00e7et's disease","volume":"17","author":"Akoglu T","year":"1990","journal-title":"J Rheumatol"},{"key":"e_1_2_5_7_2","first-page":"128","article-title":"Systemic levels of T cell regulatory cytokines IL\u201010 and IL\u201012 in Beh\u00e7et's disease; soluble TNFR\u201075 as a biological marker of disease activity","volume":"24","author":"Turan B","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_5_8_2","first-page":"1544","article-title":"Overproduction of monocyte derived tumor necrosis factor alpha, IL\u20106, IL\u20108 and increased neutrophil superoxide generation in Beh\u00e7et's disease. 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