{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T21:46:39Z","timestamp":1764193599484},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,5,18]],"date-time":"2004-05-18T00:00:00Z","timestamp":1084838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Introduction\u2002<\/jats:bold> 2\u2010Chlorodeoxyadenosine (cladribine or 2\u2010CdA) is a purine analogue that has been used successfully in hairy cell leukaemia (HCL). Moreover, it has been increasingly used to treat chronic lymphoproliferative syndromes and paediatric acute myeloid leukaemia. Cutaneous side\u2010effects associated with this drug have seldom been described in cases of HCL.<\/jats:p><jats:p><jats:bold>Patients and methods\u2002<\/jats:bold> We describe three patients with chronic lymphocytic leukaemia that presented generalized skin eruptions after treatment with 2\u2010CdA.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> All patients had advanced disease, receiving 2\u2010CdA as a second or third line chemotherapy. Skin lesions were severe and chemotherapy had to be discontinued. Histological examination of skin biopsies showed an eosinophil\u2010rich infiltrate with flame figures, similar to what is observed in Wells\u2019 syndrome (eosinophilic cellulitis). Corticosteroids were effective to control the eruptions.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Cutaneous adverse reactions associated with 2\u2010CdA have seldom been observed in the treatment of HCL. However, as this purine analogue has been used in more advanced cases these may be more frequent and severe. The pathophysiology of these lesions is unclear, but it is probably related to drug\u2010induced change in T\u2010cell imbalance in severely immunosuppressed patients.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2004.00969.x","type":"journal-article","created":{"date-parts":[[2004,8,20]],"date-time":"2004-08-20T17:14:24Z","timestamp":1093022064000},"page":"538-542","source":"Crossref","is-referenced-by-count":23,"title":["Cutaneous adverse reaction to 2\u2010chlorodeoxyadenosine with histological flame figures in patients with chronic lymphocytic leukaemia"],"prefix":"10.1111","volume":"18","author":[{"given":"MS","family":"Rossini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EM","family":"De 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