{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:02:13Z","timestamp":1767996133792,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,6,11]],"date-time":"2004-06-11T00:00:00Z","timestamp":1086912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The treatment of viral warts remains challenging. A variety of treatment modalities have been used with a range of success. Fluorouracil has been shown to be effective in treating warts but the method of its delivery directly onto the affected tissue has been of little efficacy. We evaluated the safety and efficacy of intralesional 5\u2010fluorouracil in the treatment of verrucae.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Seventy\u2010six patients with a total 315 verrucae were randomized to receive either a 5\u2010fluorouracil, lidocaine and epinephrine (5\u2010FU\u00a0+\u00a0LE) mixture or serum saline injection into the paired verrucae in the same patient. The mixture of 5\u2010FU (4\u00a0cm<jats:sup>3<\/jats:sup>, 50\u00a0mg\/mL), lidocaine (1\u00a0cm<jats:sup>3<\/jats:sup>, 20\u00a0mg\/mL) and epinephrine (0.0125\u00a0mg\/mL) was injected into the base of the wart using a mantoux needle. Each lesion was infiltrated with either of the solutions once a week for up to a maximum of 4\u00a0weeks, and the patients were followed up for 6\u00a0months.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Complete response was noted in an average of 70% of the verrucae treated with the 5\u2010FU\u00a0+\u00a0LE mixture and in 29% of those in the placebo group (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.001). No clinically significant systemic and local adverse effects occurred. Pain and burning were noted as an immediate injection pain. Recurrence rates were evaluated and no statistically significant difference between the two groups was found.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The results demonstrate that treatment of verrucae with 5\u2010FU\u00a0+\u00a0LE mixture is safe and effective.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2004.00984.x","type":"journal-article","created":{"date-parts":[[2004,6,11]],"date-time":"2004-06-11T14:43:39Z","timestamp":1086965019000},"page":"455-458","source":"Crossref","is-referenced-by-count":26,"title":["Intralesional 5\u2010fluorouracil, lidocaine and epinephrine mixture for the treatment of verrucae: a prospective placebo\u2010controlled, single\u2010blind randomized study"],"prefix":"10.1111","volume":"18","author":[{"given":"A","family":"Is\u00e7imen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EH","family":"Aydemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"G\u00f6ks\u00fcg\u00fcr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Engin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,6,11]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(85)90050-1"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70073-Q"},{"key":"e_1_2_5_4_2","first-page":"CD001781","article-title":"Local treatments for cutaneous warts","volume":"2","author":"Gibbs S","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.106365"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1001\/archderm.1997.03890370073011","article-title":"Intralesional fluorouracil\/epinephrine injectable gel for treatment of condylomata acuminata. A phase 3 clinical study","volume":"133","author":"Swinehart JM","year":"1997","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1975.tb03039.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1001\/archderm.1977.01640020068012","article-title":"Allergic contact dermatitis from topical fluorouracil","volume":"113","author":"Goette DK","year":"1977","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(80)80007-7"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70502-X"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70328-1"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000051830"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.131.11.1340"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7362.461"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2004.00984.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2004.00984.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T17:55:50Z","timestamp":1697046950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2004.00984.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,11]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1111\/j.1468-3083.2004.00984.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2004.00984.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6,11]]}}}