{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:24:31Z","timestamp":1790792671756,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,9,27]],"date-time":"2004-09-27T00:00:00Z","timestamp":1096243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The role of oxidative stress has not been fully understood in the aetiopathogenesis of vitiligo in different studies.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> We aimed to investigate the role of the oxidative stress in the pathogenesis of vitiligo.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> In this study, we examined levels of superoxide dismutase, glutathione peroxidase, malondialdehyde and nitric oxide in tissue of 25 patients with generalized vitiligo and 25 healthy controls.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Our results revealed that levels of superoxide dismutase, glutathione peroxidase and malondialdehyde in tissue were significantly increased in patients with generalized vitiligo (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). However, there was no statistically significantly difference between two groups at tissue level of nitric oxide (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Our results demonstrate the presence of an imbalance in the oxidant\u2013antioxidant system in vitiligo at tissue level and provide further support for a free radical\u2010mediated damage as an initial pathogenic event in melanocyte degeneration in vitiligo.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2004.01080.x","type":"journal-article","created":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T15:40:55Z","timestamp":1097509255000},"page":"683-686","source":"Crossref","is-referenced-by-count":68,"title":["The role of oxidants and antioxidants in generalized vitiligo at tissue level"],"prefix":"10.1111","volume":"18","author":[{"given":"M","family":"Yildirim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Baysal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HS","family":"Inaloz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Can","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,27]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"1057","volume-title":"Andrew's Diseases of the Skin.","author":"Odom RB","year":"2000"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.1993.tb00584.x"},{"key":"e_1_2_5_4_2","first-page":"945","volume-title":"Dermatology in General Medicine.","author":"Mosher DB","year":"1999"},{"key":"e_1_2_5_5_2","first-page":"111","article-title":"Diseases related to oxygen\u2010derived free radicals","volume":"25","author":"Knight JA","year":"1995","journal-title":"Ann Clin Lab"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.1999.00509.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.1998.tb00714.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02980.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12335801"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12492612"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.1994.tb00034.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)32219-7"},{"key":"e_1_2_5_13_2","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Paglia DE","year":"1967","journal-title":"J Lab Clin Med"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86135-I"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/36.8.1440"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.13.s8.9.x"},{"key":"e_1_2_5_17_2","first-page":"598","article-title":"Free radicals, antioxidants, and human diseases: where are we now?","volume":"119","author":"Halliwell B","year":"1992","journal-title":"J Lab Clin Med"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.1996.tb00098.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2003.tb00356.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199712)183:4<469::AID-PATH931>3.0.CO;2-T"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004030100211"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2004.01080.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2004.01080.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T18:42:52Z","timestamp":1697049772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2004.01080.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,27]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1111\/j.1468-3083.2004.01080.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2004.01080.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9,27]]}}}