{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:08:12Z","timestamp":1790453292046,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,11,19]],"date-time":"2004-11-19T00:00:00Z","timestamp":1100822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Melkersson\u2013Rosenthal syndrome (MRS) is a complex neuromucocutaneous disorder characterized by localized orofacial oedema and cranial nerve dysfunction, frequently associated with minor signs, including furrowed tongue. Complete forms are rare whereas mono\u2010 and oligosymptomatic variants are more common. A 71\u2010year\u2010old man presented with a 2\u2010year history of relapsing and progressively persistent oedema of the right eyelids and periorbital region. A fissured tongue and telangiectatic rosacea had been present since the age of 50 and 60\u00a0years, respectively. The patient was also affected by essential hypertension and diabetes mellitus. A skin biopsy showed a marked upper dermal oedema, and small epithelioid cell granulomas arranged in perivascular and perilymphatic location. Collections of small epithelioid cells were occasionally observed within lymphatic spaces. No acid\u2010fast bacteria, fungi or foreign bodies were detected. Intralesional corticosteroids induced transient improvement, whereas minocycline, clofazimine and dapsone have been ineffective. MRS may present with unilateral eyelid and periorbital swelling. Differential diagnoses of such cases may include a variety of cutaneous, ophthalmic and systemic diseases.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2004.01084.x","type":"journal-article","created":{"date-parts":[[2005,1,11]],"date-time":"2005-01-11T09:43:50Z","timestamp":1105436630000},"page":"107-111","source":"Crossref","is-referenced-by-count":23,"title":["Persistent unilateral orbital and eyelid oedema as a manifestation of Melkersson\u2013Rosenthal syndrome"],"prefix":"10.1111","volume":"19","author":[{"given":"B","family":"Cocuroccia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Gubinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Annessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Zambruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Girolomoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,12,10]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"737","article-title":"Case of recurrent facial paralysis with angioneurotic edema","volume":"90","author":"Melkersson E","year":"1928","journal-title":"Hygea"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02865984"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90354-S"},{"key":"e_1_2_4_5_2","first-page":"245","article-title":"Le syndrome de Melkersson\u2010Rosenthal. 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