{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:57:31Z","timestamp":1761742651588},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T00:00:00Z","timestamp":1129680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oral lichen planus (LP) is a severe, painful form of LP, and is often resistant to topical corticosteroid therapy. Recently, open trials demonstrated that topical tacrolimus therapy was effective for the treatment of chronic erosive oral LP. We report two cases with severe recalcitrant erosive oral LP, who dramatically benefited from topical tacrolimus therapy. In case 1, a 64\u2010year\u2010old man presented with a 5\u2010month history of painful erosions on his entire lower lip and buccal mucosa. Physical and histological examination confirmed a diagnosis of LP. He experienced rapid relief from pain and a dramatic improvement was obtained within 5\u00a0weeks of topical tacrolimus treatment. No significant irritation was observed and blood tacrolimus level was kept within a safe level (2.5\u00a0ng\/mL). In case\u00a02, a 68\u2010year\u2010old man developed painful erosions on his right lower lip and buccal mucosa 2\u00a0months before his arrival at our hospital. Histopathological analysis confirmed a diagnosis of oral LP. He experienced a rapid dramatic improvement of both lesions within 4\u00a0weeks of the start of tacrolimus application. No significant irritation or recurrence was observed. Thus, topical tacrolimus is suggested as a well\u2010tolerated, effective therapy for oral LP.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2005.01338.x","type":"journal-article","created":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T08:56:52Z","timestamp":1129712212000},"page":"66-68","source":"Crossref","is-referenced-by-count":34,"title":["Successful treatment of severe recalcitrant erosive oral lichen planus with topical tacrolimus"],"prefix":"10.1111","volume":"20","author":[{"given":"R","family":"Shichinohe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Shibaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Nishie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Tateishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.126275"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709183371203"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.119648"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.10.1335"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02672.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/52.14.1521"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.5.574"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120535"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199610150-00009"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1001\/archderm.1996.03890280081011","article-title":"Systemic tacrolimus (FK506) is effective for the treatment of psoriasis in a double\u2010blind, placebo\u2010controlled study","volume":"132","author":"The European FK506 Multicenter Psoriasis Study Group.","year":"1996","journal-title":"Arch Dermatol"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2005.01338.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2005.01338.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T22:32:04Z","timestamp":1697063524000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2005.01338.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,19]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1111\/j.1468-3083.2005.01338.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2005.01338.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,19]]}}}