{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:57:09Z","timestamp":1788447429509,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,4]],"date-time":"2006-01-04T00:00:00Z","timestamp":1136332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitiligo and psoriasis are both common skin disorders. However, psoriasis strictly confined to pre\u2010existing vitiligo areas is rare and suggests a causal relationship. We report here on two patients with a strict anatomical colocalization of vitiligo and psoriasis. The histopathological examinations showed typical changes for both diseases together with a dense infiltrate of CD4+ and CD8+ T\u00a0cells. By immunohistochemistry, intracytoplasmatic granzyme\u00a0B and tumour necrosis factor alpha (TNF\u2010\u03b1) were detected within the T\u2010cell population, suggesting the functional activity of these cells and the creation of a local T\u00a0helper\u00a01 (Th1)\u2010cytokine milieu. Additionally, in one patient we could identify anti\u2010melanocytic T\u00a0cells by tetramer staining and enzyme\u2010linked immunospot (ELISPOT) analysis. These skin\u2010infiltrating lymphocytes might trigger, by the local production of Th\u20101 cytokines such as TNF\u2010\u03b1 and interferon\u2010\u03b3 (IFN\u2010\u03b3), the eruption of psoriatic plaques in patients with a genetic predisposition for psoriasis.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01354.x","type":"journal-article","created":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T12:39:04Z","timestamp":1138365544000},"page":"178-183","source":"Crossref","is-referenced-by-count":19,"title":["Psoriasis confined strictly to vitiligo areas \u2013 a Koebner\u2010like phenomenon?"],"prefix":"10.1111","volume":"20","author":[{"given":"TG","family":"Berger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Kiesewetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Maczek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lueftl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Schuler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"M","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,4]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00032.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.1.246"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01605.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00805.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.11.1637"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01408.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.6.1203"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00720.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12371752"},{"key":"e_1_2_7_11_2","doi-asserted-by":"crossref","first-page":"89S","DOI":"10.1038\/jid.1995.18","article-title":"Intralesional T\u2010lymphocyte activation as a mediator of psoriatic epidermal hyperplasia","volume":"105","author":"Bata\u2010Csorgo Z","year":"1995","journal-title":"J Invest Dermatol"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1996.tb00038.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05024.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1998.tb02351.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)80158-6"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12345600"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20238"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2006.01354.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2006.01354.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T22:53:23Z","timestamp":1697064803000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2006.01354.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,4]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1111\/j.1468-3083.2006.01354.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2006.01354.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,4]]}}}