{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:51:11Z","timestamp":1791121871967,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Few articles have been published about hypertensive leg ulcers and their surgical treatment. Since mid of the year 2000, it has been our policy to treat all hypertensive leg ulcers very early with mesh split\u2010thickness skin grafts. The present series consists of 15 patients whose hypertensive leg ulcers, including five bilateral cases, were treated with 20 mesh grafts from 2000 to 2002.<\/jats:p><jats:p><jats:bold>Subjects and methods\u2002<\/jats:bold> All patients, nine women and six men, had a long history of hypertension. The same surgical procedure was applied to all 15 patients: a complete mechanical debridement of all necrotic tissues, immediately followed by mesh skin grafting.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Patients were discharged from the hospital after an average post\u2010operative period of 16\u00a0days. Upon leaving the hospital, the patients had lesions completely healed in 14 of 20 cases. The graft take had been complete after an average period of 14\u00a0days. In six cases, one or two very small patches of skin graft had necrosed and complete healing required an additional period of 1 to 3 months. In all 20 cases, pain had disappeared within 1 week from surgery.<\/jats:p><jats:p><jats:bold>Discussion\u2002<\/jats:bold> All patients were on opioid therapy before surgery. With medical treatment only, hypertensive leg ulcers used to heal after a mean period of 15\u00a0months. After surgery, the average healing period was 2 weeks and opioids were stopped within 1 month after surgery.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The review of the present series shows that early mesh grafting of hypertensive leg ulcers is beneficial, because healing is very quick and the pain will disappear quasi\u2010instantly.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01399.x","type":"journal-article","created":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T15:01:51Z","timestamp":1136991711000},"page":"166-169","source":"Crossref","is-referenced-by-count":36,"title":["A retrospective review of 20 hypertensive leg ulcers treated with mesh skin grafts"],"prefix":"10.1111","volume":"20","author":[{"given":"G","family":"Dagregorio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Guillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"337","article-title":"Ulcer of the leg due to arteriolosclerosis and ischemia, occurring in the presence of hypertensive disease (hypertensive\u2013ischemic ulcers): a preliminary report","volume":"21","author":"Hines E","year":"1946","journal-title":"Proc Staff Meet Mayo Clin"},{"key":"e_1_2_5_3_2","first-page":"128","volume-title":"L\u2019ulc\u00e8re de Jambe","author":"Coget JM.","year":"1995"},{"key":"e_1_2_5_4_2","first-page":"329","volume-title":"Plaies et Cicatrisations au Quotidien","author":"Lazareth I.","year":"2001"},{"key":"e_1_2_5_5_2","first-page":"2267","volume-title":"Rook\/Wilkinson\/Ebling Textbook of Dermatology","author":"Ryan TJ","year":"1998"},{"key":"e_1_2_5_6_2","first-page":"50","volume-title":"Th\u00e9rapeutique Dermatologique","author":"Debure C.","year":"2001"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001154"},{"key":"e_1_2_5_8_2","unstructured":"AgacheP.Ulc\u00e8res de jambe in Grands syndromes Encyclop\u00e9die M\u00e9dico\u2010Chirurgicale Ang\u00e9iologie 1997 19\u20100540."},{"key":"e_1_2_5_9_2","volume-title":"Phlebology the Guide","author":"Ramelet AA","year":"1999"},{"key":"e_1_2_5_10_2","first-page":"273","article-title":"Hypertensive ulcer of the leg (Martorell syndrome) treated by removal and skin graft","volume":"18","author":"Arcelus II","year":"1966","journal-title":"Angiologia"},{"key":"e_1_2_5_11_2","first-page":"919","article-title":"Traitement chirurgical des ulc\u00e8res de jambe par angiodermite ath\u00e9romateuse","volume":"16","author":"Moulin G","year":"1987","journal-title":"Presse Med"},{"key":"e_1_2_5_12_2","first-page":"575","article-title":"Necrotic angiodermatitis: treatment by early cutaneous grafts","volume":"122","author":"Lazareth I","year":"1995","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1995.tb02666.x"},{"key":"e_1_2_5_14_2","first-page":"1243","article-title":"Necrotic angiodermatitis treatment with Epibase","volume":"129","author":"Martin L.","year":"2002","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_5_15_2","first-page":"15","article-title":"Arteriosclerotic necrotic angiodermatitis of the lower limbs. 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