{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:05:29Z","timestamp":1783476329553,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T00:00:00Z","timestamp":1138320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Treatment of vitiligo is a challenge. Steroids are known to be effective but are associated with serious adverse effects. Many uncontrolled studies have shown calcipotriol to be a promising therapeutic modality in vitiligo.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To conduct a randomized trial to evaluate the effect of topical calcipotriol ointment (0.005%) and betamethasone dipropionate (0.05%) cream, given alone or in combination, in treatment of localized vitiligo.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Forty\u2010nine patients with vitiligo affecting 5% of their skin were recruited. Patients were randomized into three groups. Group I patients were treated with betamethasone dipropionate (0.05%) cream twice daily. Group II patients were treated with calcipotriol ointment (0.005%) twice daily, and group III with betamethasone dipropionate (0.05%) in the morning and calcipotriol (0.005%) in the evening.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Forty\u2010five patients completed the study period of 3 months with 15 patients in each group. No patient achieved excellent (&gt;\u00a075%) pigmentation. Marked (50% to 75%) repigmentation was observed in 2 (13.3%), 1 (6.7%) and 4 (26.7%) patients in groups I, II and III, respectively. Moderate (25\u201350%) repigmentation was observed in 7 (46.7%), 5 (33.3%) and 7 (46.7%) patients in groups I, II and III, respectively. Patients with &lt; 25% pigmentation were termed as minimal pigmentation or no response. The mean time for initial pigmentation to appear was 9.04\u00a0\u00b1\u00a02.0\u00a0weeks in group I, 10.18\u00a0\u00b1\u00a01.6\u00a0weeks in group II and 5.17\u00a0\u00b1\u00a02.4\u00a0weeks in group III (<jats:italic>P<\/jats:italic>\u00a0&lt; 0.01). The acquired pigmentation in the lesions was more stable in group III as compared with patients in groups II and I (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.01). Side\u2010effects in the form of atrophy and lesional burning sensations were more common in group I when compared with groups II and III (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.05).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Combined therapy appeared to give a significantly faster onset of repigmentation along with better stability of the achieved pigmentation and with lesser number of side\u2010effects.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01420.x","type":"journal-article","created":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T15:59:34Z","timestamp":1138377574000},"page":"269-273","source":"Crossref","is-referenced-by-count":62,"title":["Effect of topical calcipotriol, betamethasone dipropionate and their combination in the treatment of localized vitiligo"],"prefix":"10.1111","volume":"20","author":[{"given":"MS","family":"Kumaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1988.tb01260.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1984.01650410073019"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.12.1532"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02334.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.1999.00083.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000017991"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1976.tb02268.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000252478"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1974.tb13086.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(97)00180-6"},{"key":"e_1_2_5_12_2","first-page":"936","volume-title":"Dermatology in General Medicine","author":"Mosher DB","year":"1999"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12462151"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12480255"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2001.04381.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70077-5"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.4653_3.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02070.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90349-7"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2006.01420.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2006.01420.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:16:39Z","timestamp":1697055399000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2006.01420.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,27]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1111\/j.1468-3083.2006.01420.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2006.01420.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,27]]}}}