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Group\u00a01 received neither GH nor irradiation (control group). Group\u00a02 received 30\u00a0Gy of gamma irradiation as a single dose to the right hind legs of the rats (radiation group). Group\u00a03 and 4 received the same irradiation plus either 0.01\u00a0U\/kg\/day GH (RT\u00a0+\u00a00.01\u00a0GH group) or 0.02\u00a0U\/kg\/day GH (RT\u00a0+\u00a00.02\u00a0GH group) subcutaneously. Clinically and histopathologically, acute skin reactions were assessed by two independent experts in radiation oncology and pathology, respectively. Irradiation increased dermatitis in rats when compared with the control group. The severity of radiodermatitis in the rats in the RT\u00a0+\u00a00.01\u00a0GH and RT\u00a0+\u00a00.02\u00a0GH groups was significantly lower than that in the RT group; radiodermatitis developed earlier in the RT group than in the other groups. GH was efficacious in preventing epidermal atrophy, dermal degeneration such as oedema and collagen fibre loss, and hair follicle atrophy, but not better than in the control group. These results are preliminary to studies that will be performed with higher doses of GH in radiation\u2010treated cancer patients, with the aim of reducing radiation\u2010induced toxicity.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01454.x","type":"journal-article","created":{"date-parts":[[2006,2,9]],"date-time":"2006-02-09T17:07:59Z","timestamp":1139504879000},"page":"293-298","source":"Crossref","is-referenced-by-count":9,"title":["Is growth hormone a radioprotective 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