{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:53:56Z","timestamp":1761058436308},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T00:00:00Z","timestamp":1145577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Herpesvirus\u2010like particles have been reported to be detectable by electron microscopy in lesional biopsy of patients with pityriasis rosea (PR). We report a study investigating the association of PR with human herpesvirus\u20108 (HHV\u20108) infection.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Our setting is a teaching clinic affiliated to a university. We recruited eight patients aged 28\u201347\u00a0years (mean: 34.5\u00a0years) diagnosed with PR during a one\u2010year period. We collected acute blood specimens at presentation and convalescent blood specimens three to four weeks later. We also collected skin scrapings from the herald patch where present and from truncal secondary lesions.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> We detected HHV\u20108 DNA by a nested PCR (polymerase chain reaction) targeting, respectively, a 233\u2010bp and a 160\u2010bp fragment of ORF 26. PCR for HHV\u20108 DNA was negative in the peripheral blood mononuclear cells and plasma of acute and convalescent specimens of all patients, and negative in all skin scrapings. We detected anti\u2010HHV\u20108 IgG and IgM antibodies by the indirect immunofluorescence. Four patients had IgG antibodies against HHV\u20108, but with no significant rise of titre. None were positive for anti\u2010HHV\u20108 IgM antibody.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> We conclude that PR is not associated with HHV\u20108 infection.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01569.x","type":"journal-article","created":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T17:08:01Z","timestamp":1145639281000},"page":"667-671","source":"Crossref","is-referenced-by-count":24,"title":["The detection of human herpesvirus\u20108 DNA in plasma and peripheral blood mononuclear cells in adult patients with pityriasis rosea by polymerase chain reaction"],"prefix":"10.1111","volume":"20","author":[{"given":"AAT","family":"Chuh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PKS","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,5]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)63203-5"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000245991"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00658.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2002.290606.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.00200.x"},{"key":"e_1_2_7_7_2","first-page":"1623","article-title":"[Studies 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