{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:43:55Z","timestamp":1776980635040,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,6,9]],"date-time":"2006-06-09T00:00:00Z","timestamp":1149811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Pyogenic granuloma is a benign, acquired, proliferative vascular lesion of the skin and mucous membranes. Many different treatments have been used for pyogenic granuloma with variable success rates.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To evaluate the efficacy of cryotherapy in the treatment of pyogenic granuloma.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> In a prospective observational study, 135 patients with pyogenic granuloma were treated with cryotherapy using liquid nitrogen. The patients were followed up every 3 weeks until 3\u00a0months after disappearance of the lesion.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Complete resolution of the pyogenic granuloma was achieved in all patients after a mean of 1.58 treatments (range, 1\u20134 treatments). At the end of follow\u2010up period, there was a flat imperceptible scar, smaller than the treated lesion, in 16 patients (11.8%). A hypertrophic scar, 3\u00a0mm in diameter, was observed in one patient. Hypopigmentation was observed in seven patients (5.1%). No other complication or side\u2010effect was recorded in the study.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> We believe that pyogenic granuloma can be treated simply and effectively with cryotherapy.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01615.x","type":"journal-article","created":{"date-parts":[[2006,6,9]],"date-time":"2006-06-09T10:44:55Z","timestamp":1149849895000},"page":"788-790","source":"Crossref","is-referenced-by-count":39,"title":["Cryotherapy in the treatment of pyogenic granuloma"],"prefix":"10.1111","volume":"20","author":[{"given":"M","family":"Mirshams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Daneshpazhooh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Mirshekari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Taheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Mansoori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Hekmat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(94)90260-7"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.4.538"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-196802000-00008"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90610-6"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.2003.50092"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.1.33"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2001.01039.x"},{"key":"e_1_2_5_9_2","first-page":"18","article-title":"Pregnancy\u2010associated pyogenic granuloma of the lip: successful management using cryotherapy","volume":"67","author":"Cohen PR","year":"1996","journal-title":"J Gt Houst Dent Soc"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02760.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.5070\/D35WJ259VV","article-title":"Pyogenic granuloma arising in port\u2010wine stain after cryotherapy","volume":"9","author":"Aghaei S","year":"2003","journal-title":"Dermatol Online J"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-198006000-00005"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1991.tb00931.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199910000-00016"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.3.368"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.1999.00356.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2006.01615.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2006.01615.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T17:40:10Z","timestamp":1697046010000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2006.01615.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,9]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.1468-3083.2006.01615.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2006.01615.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,9]]}}}