{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:37:11Z","timestamp":1759333031567},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,6,6]],"date-time":"2006-06-06T00:00:00Z","timestamp":1149552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Introduction\u2002<\/jats:bold> Beh\u00e7et's disease is a rare, chronic disorder. The cause of Beh\u00e7et's disease is unknown. It is believed to be caused by an autoimmune reaction. As in other chronic autoimmune diseases, Beh\u00e7et's disease may show a subclinical adrenal failure and some changes in cortisol levels. We aimed to evaluate adrenal gland function in Beh\u00e7et's disease patients.<\/jats:p><jats:p><jats:bold>Material and method\u2002<\/jats:bold> This study included 18 Beh\u00e7et's disease patients and 15 healthy controls. Patient and control groups were administered i.v. 1\u00a0\u00b5g low dose test (LDT) and 250\u00a0\u00b5g standard dose test (SDT) adrenocorticotropic hormone (ACTH) stimulation test after 12\u00a0h of night fasting with an interval of 3\u2010days and cortisol responses in the 0th, 30th and 60th minutes were evaluated.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> There was no statistically significant difference between basal cortisol values of Beh\u00e7et's disease and control groups. Cortisol values in the 60th minute in LDT were significantly lower in Beh\u00e7et's disease group than in the control group. In the peak cortisol responses to LDT, a significant decrease was found in Beh\u00e7et's disease group.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> These findings suggest that hypothalamo\u2010pituitary adrenal axis is partially suppressed in Beh\u00e7et's disease.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01626.x","type":"journal-article","created":{"date-parts":[[2006,6,6]],"date-time":"2006-06-06T10:29:57Z","timestamp":1149589797000},"page":"721-725","source":"Crossref","is-referenced-by-count":6,"title":["A comparison between the effects of low (1\u00a0\u00b5g) and standard dose (250\u00a0\u00b5g) ACTH stimulation tests on adrenal cortex functions with Beh\u00e7et's disease"],"prefix":"10.1111","volume":"20","author":[{"given":"R","family":"Colak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Ozkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SU","family":"Cengiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Saral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BC","family":"Kandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Halifeoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,6]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"1420","volume-title":"Arthitis and Allied Conditions. 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