{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:58:30Z","timestamp":1760367510715},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,8,16]],"date-time":"2006-08-16T00:00:00Z","timestamp":1155686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Recurrent and painful ulcers of the oral mucosa and genital skin\/mucosa are the most commonly observed manifestations in patients with Beh\u00e7et's disease (BD). They affect patients\u2019 quality of life. Because of the effectiveness of granulocyte colony\u2010stimulating factor (G\u2010CSF) in wound healing, it may also be useful for the treatment of oral ulcers (OU) and genital ulcers (GU) of BD.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> We aimed to determine the efficacy of topically applied G\u2010CSF in the treatment of OU and GU of BD.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Seven patients with BD diagnosed according to the criteria of the International Study Group for Beh\u00e7et's Disease were involved in the study. The patients were observed for 3\u00a0months before the study, and all occurrences were recorded during this period. Patients were given topical G\u2010CSF for OU (4\u00a0\u00d7\u00a0120 \u00b5g\/day, for 5\u00a0days) and\/or GU (4\u00a0\u00d7\u00a030\u00a0\u00b5g\/day, for 5\u00a0days) and followed\u2010up for 3\u00a0months after treatment. No concurrent disease\u2010specific or immunosuppressive topical or systemic drugs were given during the study period.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> G\u2010CSF treatment decreased the healing time and pain of OU and GU in six of seven patients compared with the pretreatment period. However, the effectiveness of the G\u2010CSF treatment on OU and GU healing time and pain severity did not continue during the post\u2010treatment period.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> G\u2010CSF has beneficial effects on the healing duration and pain severity of OU and GU of patients with BD. However, given the high cost, impractical preparation and inability to cure the disease, G\u2010CSF treatment should be chosen only in selected patients.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01677.x","type":"journal-article","created":{"date-parts":[[2010,9,20]],"date-time":"2010-09-20T15:32:52Z","timestamp":1284996772000},"page":"931-935","source":"Crossref","is-referenced-by-count":15,"title":["Topical granulocyte colony\u2010stimulating factor for the treatment of oral and genital ulcers of patients with Beh\u00e7et's disease"],"prefix":"10.1111","volume":"20","author":[{"given":"A","family":"Bacanli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Yerebakan Dicle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Parmaksizoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Alpsoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000074113"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.5.529"},{"key":"e_1_2_6_4_2","first-page":"532","article-title":"Beh\u00e7et's disease: treatment of mucocutaneous lesions","volume":"23","author":"Alpsoy E","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_5_2","first-page":"325","article-title":"Granulocyte\u2010macrophage colony\u2010stimulating factor and granulocyte colony\u2010stimulating factor: differential action on incisional wound healing","volume":"115","author":"Jyung RW","year":"1994","journal-title":"Surgery"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02385906"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1326.2001.00142.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702024"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1997.tb02170.x"},{"key":"e_1_2_6_10_2","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease","author":"International Study Group for Beh\u00e7et's Disease.","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02990841"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115107"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.5.570"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411006"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(99)00065-4"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(99)00064-2"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03263.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00665.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2002.11.4.26391"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2006.01677.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2006.01677.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T16:55:05Z","timestamp":1697043305000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2006.01677.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,16]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1468-3083.2006.01677.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2006.01677.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,16]]}}}