{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:33:02Z","timestamp":1790346782310,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T00:00:00Z","timestamp":1160524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold>Oral terbinafine and oral itraconazole are two of the most common agents used for the treatment of toenail dermatophyte onychomycosis. Despite the fact that diabetic patients are more likely to have onychomycosis than normal individuals are, there is little research into the efficacy of standard oral regimens of terbinafine and itraconazole for onychomycosis in the diabetic population.<\/jats:p><jats:p><jats:bold>Study design\u2002<\/jats:bold>We present a prospective, randomized, single\u2010blind, parallel group, comparator\u2010controlled, multi\u2010centre study designed to assess the efficacy of the pulse itraconazole (200\u00a0mg twice daily, 1\u00a0week on, 3\u00a0weeks off, for 12\u00a0weeks) vs. continuous terbinafine (250\u00a0mg once daily for 12\u00a0weeks) oral therapies in the treatment of dermatophyte toenail distal and lateral subungual onychomycosis (DLSO) in the diabetic population.<\/jats:p><jats:p><jats:bold>Efficacy parameters\u2002<\/jats:bold>Primary efficacy measures included mycological cure rate (negative KOH and culture) and effective cure (mycological cure plus nail plate involvement of 10% or less) at Week 48.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>At Week 48, mycological cure was attained by 88.2% (30 of 34) and 79.3% (23 of 29) of patients in the itraconazole and terbinafine groups, respectively (<jats:italic>P<\/jats:italic>not significant). Effective cure (mycological cure with \u2264\u00a010% of nail plate involvement) was attained by 52.9% (18 of 34) of the itraconazole group and 51.7% (15 of 29) of the terbinafine group (<jats:italic>P<\/jats:italic>not significant). Three itraconazole patients experienced side effects in the form of gastrointestinal problems. There were no serious adverse events and no interactions with concomitant medications recorded.<\/jats:p><jats:p><jats:bold>Discussion\u2002<\/jats:bold>Both continuous terbinafine and itraconazole pulse therapy are effective and safe in the management of dermatophyte toenail onychomycosis in people with diabetes.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01698.x","type":"journal-article","created":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T09:26:05Z","timestamp":1160558765000},"page":"1188-1193","source":"Crossref","is-referenced-by-count":32,"title":["Pulse itraconazole vs. continuous terbinafine for the treatment of dermatophyte toenail onychomycosis in patients with diabetes mellitus"],"prefix":"10.1111","volume":"20","author":[{"given":"AK","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MD","family":"Gover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CW","family":"Lynde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90063-8"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.110376"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02464.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1047"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04606.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.104794"},{"key":"e_1_2_5_8_2","unstructured":"KejdaJ.Itraconazole pulse therapy vs. continuous terbinafine dosing for toenail onychomycosis.Postgrad Med1999: Spec No:12\u201315."},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.110874"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04606.x"},{"key":"e_1_2_5_11_2","first-page":"11","article-title":"[Hypoglycemia induced by oral hypoglycemic agents. Records of the French Regional Pharmacovigilance Centers 1985\u20131990]","volume":"143","author":"Girardin E","year":"1992","journal-title":"Ann Med Interne (Paris)"},{"key":"e_1_2_5_12_2","unstructured":"USP DI \u2013 Drug Information for the Health Care Professional.Thomson MICROMEDEX CO: Greenwood Village 2004:841\u2013843."},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200038020-00002"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000018152"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-89-7-339"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0090-9556(24)15022-2","article-title":"Multiple cytochrome P\u2010450s involved in the metabolism of terbinafine suggest a limited potential for drug\u2013drug interactions","volume":"27","author":"Vickers AE","year":"1999","journal-title":"Drug Metab Dispos"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2006.01698.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2006.01698.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T10:59:23Z","timestamp":1736593163000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2006.01698.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,16]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1468-3083.2006.01698.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2006.01698.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,16]]}}}