{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:47:02Z","timestamp":1761630422927},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,8,30]],"date-time":"2006-08-30T00:00:00Z","timestamp":1156896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CD4+\/CD56+ hematodermic neoplasm, formerly known as blastic NK cell lymphoma, is an aggressive and rare preculsor hematologic neoplasm recently recognized by the WHO\u2010EORTC classification consensus for cutaneous lymphomas. The neoplasm tends to affect elderly patients, who usually present with skin lesions but often have a disseminated disease, including bone marrow involvement. Although the lesions are composed of cells with a lymphoblast\u2010like morphology and an NK\u2010cell phenotype, exhibiting a CD4+, CD56+ positive immunophenotype, recent studies support a relationship to plasmacytoid dendritic cells. Because of the rarity of this disease, we describe two patients suffering a CD4+\/CD56+ hematodermic neoplasm.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01743.x","type":"journal-article","created":{"date-parts":[[2006,8,30]],"date-time":"2006-08-30T09:43:49Z","timestamp":1156931029000},"page":"1129-1132","source":"Crossref","is-referenced-by-count":17,"title":["CD4+\/CD56+ haematodermic neoplasm: a preculsor haematological neoplasm that frequently first presents in the skin"],"prefix":"10.1111","volume":"20","author":[{"given":"JM","family":"Mart\u00edn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MJ","family":"Nicolau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Gal\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ferr\u00e1ndez\u2010Izquierdo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AM","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Jord\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,30]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03527.x"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.45"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05227.x"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00661.x"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199902000-00001"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.12.010"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.118339"},{"key":"e_1_2_4_10_2","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.4049\/jimmunol.146.12.4421","article-title":"Molecular and functional analysis of human natural killer cell\u2010associated neural cell adhesion molecule (NCAM\/CD56)","volume":"146","author":"Lanier LL","year":"1991","journal-title":"J Immunol"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200207000-00003"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2006.01743.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2006.01743.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T18:14:48Z","timestamp":1697048088000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2006.01743.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,30]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1111\/j.1468-3083.2006.01743.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2006.01743.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,30]]}}}