{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:36:02Z","timestamp":1784752562523,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,8,31]],"date-time":"2006-08-31T00:00:00Z","timestamp":1156982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> \u2002Some studies have shown discrepancies in human leucocyte antigen (HLA) associated with alopecia areata (AA) between different ethnic populations.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To investigate whether HLA\u2010I, \u2010DQA1 and \u2010DQB1 alleles and the HLA haplotype are associated with AA, and the correlation between the HLA haplotype profile, age of onset and severity of AA in Chinese Hans.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> The polymerase chain reaction\u2010sequence specific primer (PCR\u2010SSP) method was used to analyse the frequencies of HLA class I, \u2010DQA1 and \u2010DQB1 alleles in 192 patients with AA and 252 controls in Chinese Hans. The linkage disequilibrium was calculated using the 2\u00a0\u00d7\u00a02\u00a0table.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The 24 two\u2010locus haplotypes [including A*02\u2010B*18, A*02\u2010B*27, A*02\u2010B*52, A*02\u2010Cw*0704, A*02\u2010DQA1*0104, A*02\u2010DQB1*0604, A*02\u2010DQB1*0606, B*18\u2010Cw*0704, B*18\u2010DQA1*0104, B*18\u2010DQA1*0302, B*18\u2010DQB1*0606, B*27\u2010Cw*0704, B*27\u2010DQA1*0104, B*27\u2010DQA1*0302, B*52\u2010Cw*0704, B*52\u2010DQA1*0104, B*52\u2010DQA1*0302, B52\u2010DQB1*0606, Cw*0704\u2010DQA1*0104, Cw*0704\u2010DQA1*0302, Cw*0704\u2010DQB1*0606, DQA1*0104\u2010DQB1*0604, DQA1*0104\u2010DQB1*0606, DQA1*0302\u2010DQB1*0606 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05)] were associated with AA, while eight extended haplotypes (A*02\u2010B*18\u2010DQA1*0104, A*02\u2010B*27\u2010DQA1*0104, A*02\u2010B*52\u2010DQA1*0104, A*02\u2010B*52\u2010DQA1*0302, A*02\u2010B*52\u2010DQB1*0606, B*52\u2010Cw*0704\u2010DQA1*0104, B*52\u2010Cw*0704\u2010DQA1*0302, A*02\u2010B*52\u2010DQA1*0302\u2010DQB1*0606) were found to be related to AA in Chinese Hans. Through stratified analysis, we found that the extended haplotype B*52\u2010Cw*0704\u2010DQA1*0302 was related to early onset of AA, and no haplotype was only associated with severe AA.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> \u2002This is the first detailed report to elucidate HLA haplotypes associated with AA and that demonstrates the significant HLA haplotypes in Chinese Hans AA. The haplotype B*52\u2010Cw*0704\u2010DQA1*0302 was identified to be related to early onset of AA. Our results provide some information for future research on predisposing genes in HLA regions in Chinese Hans.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01750.x","type":"journal-article","created":{"date-parts":[[2006,8,31]],"date-time":"2006-08-31T10:17:18Z","timestamp":1157019438000},"page":"1207-1213","source":"Crossref","is-referenced-by-count":13,"title":["Association of HLA haplotype with alopecia areata in Chinese 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