{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:40:58Z","timestamp":1791484858566,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T00:00:00Z","timestamp":1160524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Isotretinoin is the only drug that affects almost all factors in acne pathogenesis. Recently, its use for the treatment of chronic mild or moderate acne unresponsive to long\u2010term antibiotic therapy, and with a tendency to cause scarring and leading to negative psychological effects, has became popular. The aim of the study was to investigate the effectiveness of intermittent isotretinoin treatment in mild or moderate acne.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Sixty patients with mild or moderate acne localized to the face were enrolled in the study. The treatment regimen consisted of isotretinoin, 0.5\u20130.75\u00a0mg\/kg per day, applied for 1\u00a0week every 4\u00a0weeks for a total period of 6\u00a0months, according to the degree of acne and number of inflammatory lesions.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Forty\u2010one (68.3%) of the 60 patients completed the 6\u2010month therapy. At the end of the treatment complete improvement was observed in 34 patients (82.9%) out of 41. All adverse effects were mild and discontinuation of the treatment was not necessary.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Intermittent isotretinoin treatment was found to be a safe and effective choice for patients with mild or moderate acne.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01784.x","type":"journal-article","created":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T09:26:05Z","timestamp":1160558765000},"page":"1256-1260","source":"Crossref","is-referenced-by-count":32,"title":["The effectiveness of intermittent isotretinoin treatment in mild or moderate 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