{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:56:37Z","timestamp":1790186197077,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T00:00:00Z","timestamp":1162857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Beh\u00e7et's disease (BD) is a systemic inflammatory disease of unknown aetiology. The pathogenesis of rheumatological findings and the status of bone metabolism in this disease are unknown. Inflammatory diseases may predispose to a decrease in bone mineral density (BMD) and there are many studies concerning osteoporosis in chronic inflammatory diseases.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> The aim of this study was to investigate BMD and bone turnover markers in patients with BD.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Thirty BD patients (17 male and 13 female patients, mean age 36.9\u00a0\u00b1\u00a012.6\u00a0years) and a total of 30 age\u2010 and sex\u2010matched healthy controls (17 male and 13 female controls, mean age 34.9\u00a0\u00b1\u00a08.95\u00a0years) recruited from the general population were enrolled in the study. Bone mineral density was measured at the lumbar spine (L1\u20104) and the left hip (total hip) using dual energy X\u2010ray absorptiometry. Serum samples were collected between 8 and 10\u00a0am after overnight fasting. Serum calcium (Ca), phosphate (P), parathormone (PTH), total alkaline phosphatase (ALP), osteocalcin (OC), erythrocyte sedimentation rate (ESR), and C\u2010reactive protein (CRP) were measured. Free deoxypyridinoline cross\u2010links (DPD) in second\u2010void urine and total daily urinary calcium excretion were analysed.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> No statistically significant difference in lumbar spine or femoral BMD and bone turnover markers were found between BD patients and control groups (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Although it is difficult to draw definite conclusions because of the limited number of patients involved, our study indicates that bone mineral density and bone turnover markers in Beh\u00e7et's disease were no different than in healthy subjects.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01845.x","type":"journal-article","created":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T15:42:06Z","timestamp":1162914126000},"page":"25-29","source":"Crossref","is-referenced-by-count":9,"title":["Bone mineral density and bone turnover markers of patients with Beh\u00e7et's disease"],"prefix":"10.1111","volume":"21","author":[{"given":"NS","family":"Tekin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ozdolap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sarikaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Esturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Gumustas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.12.1171"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.43.6.783"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(98)80001-2"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2001.19819"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.5.505"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009749709115831"},{"key":"e_1_2_5_8_2","first-page":"80","article-title":"Characteristics of peripheral arthritis in Beh\u00e7et's disease","volume":"110","author":"Calguneri M","year":"1997","journal-title":"N Z Med J"},{"key":"e_1_2_5_9_2","first-page":"299","article-title":"Joint manifestations in Beh\u00e7et's disease. A review of 340 cases","volume":"65","author":"Benamour S","year":"1998","journal-title":"Rev Rhum Engl Ed"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/35046196"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11089"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2002.0882"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/8756-3282(95)00180-L","article-title":"Role of cytokines in bone resorption","volume":"16","author":"Manolagas SCV","year":"1995","journal-title":"Bone"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03354648"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1191\/0961203302lu261oa"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/030097402320318387"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01684.x"},{"key":"e_1_2_5_18_2","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease","volume":"335","author":"International Study Group for Beh\u00e7et's Disease.","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar67"},{"key":"e_1_2_5_20_2","first-page":"17","volume-title":"Osteoporosis: Diagnosis and Management.","author":"Mundy GR"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/32.5.387"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21110"},{"key":"e_1_2_5_23_2","first-page":"2236","article-title":"Evaluation of bone mineral density, hormones, biochemical markers of bone metabolism, and osteoprotegerin serum levels in patients with ankylosing spondylitis","volume":"31","author":"Franck H","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_5_24_2","first-page":"1430","article-title":"Ankylosing spondylitis, psoriatic arthritis, and reactive arthritis show increased bone resorption, but differ with regard to bone formation","volume":"29","author":"Grisar J","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_5_25_2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00296-002-0250-7","article-title":"Predictors of bone mineral density and osteoporosis in patients attending a rheumatology outpatient clinic","volume":"23","author":"Lee YH","year":"2003","journal-title":"Rheumatol Int"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199911)42:11<2319::AID-ANR9>3.0.CO;2-G"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/31.3.149"},{"key":"e_1_2_5_28_2","first-page":"1282","article-title":"Osteoclastic activation is the principal mechanism leading to secondary osteoporosis in rheumatoid arthritis","volume":"25","author":"Gough A","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-003-0381-5"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-56-662-87"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-003-0302-7"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(03)00244-5"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/70.1.97"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/67.4.734"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91049-9"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.1.21"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.12.1256"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2006.01845.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2006.01845.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T22:25:01Z","timestamp":1696976701000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2006.01845.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,7]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1468-3083.2006.01845.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2006.01845.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,7]]}}}