{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T20:44:42Z","timestamp":1771879482535,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T00:00:00Z","timestamp":1169683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Antibiotics are often combined with other agents to provide topical acne treatments that are effective against both inflammatory and non\u2010inflammatory lesions and minimize the development of antibiotic resistance.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To compare the clinical effectiveness of two combination treatments for facial acne: a ready mixed, once daily gel containing clindamycin phosphate (1%) plus benzoyl peroxide (5%) (CDP\u00a0+\u00a0BPO) and a twice daily solution of erythromycin (4%) plus zinc acetate (1.2%) (ERY\u00a0+\u00a0Zn).<\/jats:p><jats:p><jats:bold>Methods\/patients\u2002<\/jats:bold> In this assessor\u2010blind, randomized study, 73 patients were treated with CDP\u00a0+\u00a0BPO once daily and 75 patients with ERY\u00a0+\u00a0Zn twice daily. The treatment period was 12\u00a0weeks and lesion counts and global improvement were assessed at weeks 1, 2, 4, 8 and 12.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> CDP\u00a0+\u00a0BPO showed an earlier onset of action with a faster significant reduction in total lesion counts than ERY\u00a0+\u00a0Zn. The proportion of patients with at least a 30% improvement in non\u2010inflammatory lesions at week\u00a01 was 31.5% for CDP\u00a0+\u00a0BPO and 17.3% for ERY\u00a0+\u00a0Zn; the corresponding percentages for inflammatory lesions were 39.7% and 29.3%. A difference was also observed at week\u00a02 (53.4% vs. 36.0% for non\u2010inflammatory lesions and 72.6% vs. 53.3% for inflammatory lesions). The trend in favour of CDP\u00a0+\u00a0BPO, although less marked, continued to the end of the study, with reductions in the total lesion count at endpoint of 69.8% for CDP + BPO group and 64.5% for ERY + Zn group. Both treatments were well tolerated.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> CDP\u00a0+\u00a0BPO and ERY\u00a0+\u00a0Zn are effective treatments for acne but CDP\u00a0+\u00a0BPO has an earlier onset of action that should improve patient compliance.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01884.x","type":"journal-article","created":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T14:11:37Z","timestamp":1169734297000},"page":"311-319","source":"Crossref","is-referenced-by-count":46,"title":["A randomized, single\u2010blind comparison of topical clindamycin +\u00a0benzoyl peroxide (Duac<sup>\u00ae<\/sup>) and erythromycin\u00a0+\u00a0zinc acetate (Zineryt<sup>\u00ae<\/sup>) in the treatment of mild to moderate facial acne vulgaris"],"prefix":"10.1111","volume":"21","author":[{"given":"A","family":"Langner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Sheehan\u2010Dare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Layton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2000.03.945"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.618"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05067.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb00104.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304120-00002"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70177-4"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102040-00007"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(02)80023-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(83)70211-2"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1365-2133.1996.d01-733.x","article-title":"The effect of acne treatment with a combination of benzoyl peroxide and erythromycin on skin carriage of erythromycin\u2010resistant propionibacteria","volume":"134","author":"Eady EA","year":"1996","journal-title":"Br J Dermatol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0934-8840(99)80084-X"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb15124.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb02929.x"},{"key":"e_1_2_6_15_2","unstructured":"Zineryt.Summary of product characteristics. 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