{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:54:37Z","timestamp":1791806077726,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T00:00:00Z","timestamp":1165276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Large series of chemotherapy\u2010induced nail changes in children have rarely been reported in the literature.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To study the pattern and onset of nail changes in cancer children receiving various chemotherapy regimens.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A cross\u2010sectional study was performed on 30 paediatric patients (aged 1\u201317, mean 8.3\u00a0years), including 11 with acute lymphoblastic leukaemia, five with acute myeloid leukaemia, and others.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Nail changes developed in 10 children during chemotherapy, five of whom had Muehrcke's lines, three Beau's lines, one Mees\u2019 lines and another had trachyonychia. There appeared to be no correlation between the pattern of nail alteration and the underlying cancer types or stages, or the regimens of chemotherapy.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> One third of the children with cancers developed nail changes associated with chemotherapy. Among them, Muehrcke's lines were the most common manifestation, which were unrelated to hypoalbuminaemia in our series.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01887.x","type":"journal-article","created":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T14:43:28Z","timestamp":1165329808000},"page":"186-190","source":"Crossref","is-referenced-by-count":48,"title":["Nail changes associated with chemotherapy in children"],"prefix":"10.1111","volume":"21","author":[{"given":"W","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u2010S","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u2010H","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u2010M","family":"Sheen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u2010C","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(84)70032-6"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2001.04391.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg050"},{"key":"e_1_2_5_5_2","first-page":"610","article-title":"Severe nail changes due to docetaxel treatment","volume":"13","author":"Rafi L","year":"2003","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C190"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.07.057"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1974.00320210107015"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/23.4.557"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01727.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1997.tb00222.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1001\/archderm.1983.01650280062018","article-title":"Chemotherapy\u2010induced transverse white lines in the fingernails","volume":"119","author":"James WD","year":"1983","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1001\/archinte.1979.03630390094033","article-title":"Muehrcke's lines of the fingernails","volume":"139","author":"Schwartz RA","year":"1979","journal-title":"Arch Intern Med"},{"key":"e_1_2_5_14_2","first-page":"656","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"Baran R","year":"2003"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-86183-3"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000070954"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2006.01887.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2006.01887.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T22:59:08Z","timestamp":1696978748000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2006.01887.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,20]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1468-3083.2006.01887.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2006.01887.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,20]]}}}