{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:20:01Z","timestamp":1783704001703,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T00:00:00Z","timestamp":1164672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Linkage and association studies suggest that the human leucocyte antigen (HLA) region may be involved in the genetic susceptibility of vitiligo. HLA\u2010A2 has been reported to be associated with vitiligo in some, but not all, studies.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To identify sources of the heterogeneity among studies and to quantify effect estimates, we examined the association of HLA\u2010A2 with vitiligo in a meta\u2010analysis of all observational studies comparing the frequencies of HLA\u2010A2 between vitiligo individuals and controls during 1966\u20132005.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> The summary odds ratio (OR) was calculated by using a fixed\u2010 or a random\u2010effects model. Meta\u2010regression analysis was undertaken to investigate the effects of study characteristics on the pooled OR.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Eleven case\u2010controlled studies fulfilled our inclusion criteria. The studies identified a total of 777 patients and 4820 controls. Meta\u2010analysis showed a significantly increased frequency of HLA\u2010A2 in vitiligo among cases [OR\u00a0=\u00a02.07, 95% confidence interval (CI) 1.67\u20132.58]. Heterogeneity was explained by the quality of the study and the ethnic background of the participants. Meta\u2010regression analysis further showed that the percentage of familial vitiligo among the subjects had a significant effect on the pooled OR (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.008). No study had a significant effect on the pooled OR and no publication bias presented in the studies analysed (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.688).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> These findings strongly suggest an association between HLA\u2010A2 and vitiligo.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01899.x","type":"journal-article","created":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T19:35:56Z","timestamp":1164742556000},"page":"205-213","source":"Crossref","is-referenced-by-count":60,"title":["Association of vitiligo with HLA\u2010A2: a meta\u2010analysis"],"prefix":"10.1111","volume":"21","author":[{"given":"J\u2010B","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u2010Q","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W\u2010D","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u2010H","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u2010S","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X\u2010J","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MP","family":"Zeegers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.044"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470760116"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916930108994127"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.01813.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91709-4"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.1.246"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711700209"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780138"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01408.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01363.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12413.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.6.973"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.212221199"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/10245330290028605"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02389.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2004.05.003"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1978.tb01349.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000250480"},{"key":"e_1_2_6_20_2","unstructured":"MinevM TonkinN MartinovaF.Association of the HLA system with vitiligo[in Russian].Vestn Dermatol Venerol1985;5:41\u201342."},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb03167.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000247240"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/1993\/356874"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1995.tb00427.x"},{"key":"e_1_2_6_25_2","first-page":"23","article-title":"Vitiligo is associated with HLA\u2010A2 and HLA\u2010Dw7 in the Slovak populations","volume":"42","author":"Buc M","year":"1996","journal-title":"Folia Biol (Praha)"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00141.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb025007"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb022863"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1086\/430279"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(81)90056-8"},{"key":"e_1_2_6_31_2","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel N","year":"1959","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_6_34_2","unstructured":"SteichenTJ EggerM SterneJ.Tests for publication bias in meta\u2010analysis.Stata Technical Bulletin1998: STB\u201044:sbe19.1."},{"key":"e_1_2_6_35_2","first-page":"31","article-title":"A study on the association of HLA antigens with vitiligo","volume":"23","author":"Dai X","year":"1990","journal-title":"Chin J Dermatol"},{"key":"e_1_2_6_36_2","first-page":"407","article-title":"Study on association between vitiligo and HLA class I antigens","volume":"33","author":"Wang Y","year":"2000","journal-title":"Chin J Dermatol"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90718-5"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2004.tb00514.x"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-002-0687-5"},{"key":"e_1_2_6_40_2","first-page":"13","article-title":"Occurrence rates of HLA\u2010DRB1, HLA\u2010DQB1, and HLA\u2010DPB1 alleles in patients suffering from vitiligo","volume":"8","author":"Buc M","year":"1998","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04288.x"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1086\/378900"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.23.9194"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1533209100"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02610.x"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00196.x"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2004.06.008"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-0749.2003.00105.x"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2002.00057.x"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-002-0295-1"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364243"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-005-0585-5"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2006.01899.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2006.01899.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T22:58:23Z","timestamp":1696978703000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2006.01899.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,20]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1468-3083.2006.01899.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2006.01899.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,20]]}}}