{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:41:01Z","timestamp":1782754861862,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T00:00:00Z","timestamp":1164672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Because of its effects on quality of life, acne vulgaris is more than a merely physiological or cosmetic entity.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To describe the influence of mild to moderate acne on patients\u2019 quality of life, measured using Skindex\u201029, and to correlate changes in Skindex\u201029 scores with changes in objective and subjective indices in clinical severity after treatment with topical 4% erythromycin 0.2% zinc. Also, to evaluate efficacy and side\u2010effects of the treatment.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Observational, prospective study of 1878 patients cared for by 252 clinicians in Spain. Data included epidemiological information and responses to Skindex\u201029, a subjective change and objective severity index.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Baseline Skindex scale scores were worse in women, older patients, and those with more severe clinical disease. Skindex was sensitive to changes in objective severity but changes in Skindex scale scores were also related to other factors. Patients who reported their skin condition to be \u2018the same\u2019 or \u2018worse\u2019 at the end of the study had significantly worse baseline scores on the \u2018symptoms\u2019 and \u2018emotions\u2019 scales but \u2018functioning\u2019 scores were not worse than for those who reported their condition had improved.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The effects of acne vulgaris on quality of life and changes in quality of life after treatment are not only explainable by objective severity of acne. Patients\u2019 and clinicians\u2019 judgements about acne severity are different.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01907.x","type":"journal-article","created":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T19:35:56Z","timestamp":1164742556000},"page":"219-226","source":"Crossref","is-referenced-by-count":57,"title":["Quality of life in mild to moderate acne: relationship to clinical severity and factors influencing change with 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