{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:37:52Z","timestamp":1791506272728,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,12,8]],"date-time":"2006-12-08T00:00:00Z","timestamp":1165536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Acne is a multifactorial disorder in which the sebum plays an important pathogenetic role.<\/jats:p><jats:p><jats:bold>Purpose of the study\u2002<\/jats:bold> To evaluate the sebostatic effect of three anti\u2010acneic ingredients (azelaic acid, adapalene and benzoyl peroxide) conveyed in cream and to determine whether there is a correlation with the therapeutic results.<\/jats:p><jats:p><jats:bold>Materials and methods\u2002<\/jats:bold> Sixty\u2010five patients with mild or moderate acne localized on the face were divided into three therapy groups at random: 25 applied azelaic acid once a day, 20, benzoyl peroxide and 20, adapalene. All the patients were observed at the time of enrolling and a further four times at fortnightly intervals. At each visit the sebum casual level on the forehead, chin and one cheek was measured using a sebumeter. Furthermore, side\u2010effects and clinical\u2010therapeutic effectiveness were noted.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Four patients did not complete the study. Azelaic acid showed an average reduction of 13.9% in sebum production on the forehead, 14.2% on the chin and 15.2% on the cheek. Benzoyl peroxide caused an increase of 10.5% in sebum production on the forehead, 10.3% on the chin and 25.4% on the cheek. Adapalene reduced sebaceous secretion by 0.2% on the forehead and 6.7% on the cheek whereas sebum production increased by 6.2% on the chin. All three drugs showed a clinical improvement in the acneic lesions with moderate adverse effects.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The three topical drugs bring about good therapeutic results with scarce side\u2010effects that do not, however, seem to be correlated with the sebostatic activity.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01914.x","type":"journal-article","created":{"date-parts":[[2006,12,8]],"date-time":"2006-12-08T09:29:34Z","timestamp":1165570174000},"page":"320-325","source":"Crossref","is-referenced-by-count":36,"title":["Relationship between sebostatic activity, tolerability and efficacy of three topical drugs to treat mild to moderate acne"],"prefix":"10.1111","volume":"21","author":[{"given":"G","family":"Stinco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Bragadin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Trotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Pillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Patrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90416-6"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08590.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.03.004"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.03.009"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03249.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000247853"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.1995.tb00111.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000017845"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1970.tb12431.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)01154-X"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363150-00005"},{"key":"e_1_2_5_13_2","first-page":"455","article-title":"Meccanismo d\u2019azione dell\u2019azelaic acid nell\u2019acne","volume":"124","author":"Passi S","year":"1989","journal-title":"G Ital Dermatol Venereol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/09546638909094474"},{"key":"e_1_2_5_15_2","first-page":"20","article-title":"Effects of azelaic acid on sebaceous gland, sebum excretion rate and keratinization pattern in human skin. 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