{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:40:21Z","timestamp":1783485621507,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,12,8]],"date-time":"2006-12-08T00:00:00Z","timestamp":1165536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The epidemiology of alopecia areata (AA) is well documented in adults but has not been studied adequately in children.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To evaluate the clinical and epidemiological profile of AA in children and assess the significance of thyroid screening.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> One hundred and fifty\u2010seven children (83 boys, 74 girls, aged 1\u201316\u00a0years) who visited our clinic with a first episode of AA from 1996 to 2000 were retrospectively studied. One hundred children served as clinical controls.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The age of peak incidence of AA was 0\u20135\u00a0years. The youngest child was 1\u00a0year old. In the majority of the cases (131\/157, 83.4%) the disease was mild or moderate (less than 50% hair loss). In 15 patients (9.5%), AA was preceded by a stressful event. Five patients had a personal history of autoimmune disease (3.2 vs. 5% of the controls, (<jats:italic>P<\/jats:italic>\u00a0=\u00a0not significant [NS]) while 18 patients had a personal history of atopy (11.4 vs. 18% of the controls, <jats:italic>P<\/jats:italic>\u00a0=\u00a0NS). Twenty\u2010one patients had a family history of autoimmune disease other than thyroiditis (13.4 vs. 5% of the controls, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), while 23 patients had a family history of thyroid disorder (14.6 vs. 3% of the controls, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006). In eight patients (5%) subclinical hypothyroidism of autoimmune aetiology (Hashimoto's thyroiditis) was revealed at the time of investigation. Six out of the eight patients with Hashimoto's thyroiditis had a family history of thyroid disorder, which was statistically significant when compared to AA patients without thyroiditis (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.001). The severity of AA was associated with early age of onset of the disease (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.02).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The age of peak incidence of AA in children is 0\u20135\u00a0years. Children with AA have an increased family history of autoimmunity, and, among children with a first episode and short duration of AA (&lt;\u00a06\u00a0months), thyroid screening might be restricted in those with a positive family history of thyroid disorder. Thyroid screening should be routinely performed in all children with long\u2010standing AA.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.01931.x","type":"journal-article","created":{"date-parts":[[2006,12,8]],"date-time":"2006-12-08T09:29:34Z","timestamp":1165570174000},"page":"356-359","source":"Crossref","is-referenced-by-count":51,"title":["A case series of alopecia areata in children: impact of personal and family history of stress and autoimmunity"],"prefix":"10.1111","volume":"21","author":[{"given":"T","family":"Kakourou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Karachristou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Chrousos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1087-0024.2003.00811.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1992.tb03932.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1994.tb02921.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.01357.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70170-4"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1996.tb00703.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2002.00088.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2002.00215.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2002.00216.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2005.01971.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70195-7"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.4065\/76.4.413"},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/1523-1747.ep12471869","article-title":"Alopecia areata: clinical aspects","volume":"96","author":"Price V","year":"1991","journal-title":"J Invest Dermatol"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1963.01590210048007"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1989.tb02604.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1994.tb00562.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)80009-1"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","unstructured":"EsterlyN ed.Alopecia areata symposium.Pediatr Dermatol1987; 4:136\u2013158.","DOI":"10.1111\/j.1525-1470.1987.tb00768.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.103909"},{"key":"e_1_2_5_21_2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2340\/0001555572279280","article-title":"Can alopecia areata be triggered by emotional stress?","volume":"72","author":"Van der Steen P","year":"1992","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000051732"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.03.032"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2006.01931.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2006.01931.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T23:12:16Z","timestamp":1696979536000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2006.01931.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,8]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1111\/j.1468-3083.2006.01931.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2006.01931.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,8]]}}}