{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:59:05Z","timestamp":1760266745379},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,1,31]],"date-time":"2007-01-31T00:00:00Z","timestamp":1170201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Psoriasis vulgaris is a skin disease with a complex immunological and genetic background, triggered by environmental factors. The association of human leukocyte antigens (HLA) and psoriasis has long been reported on population and familial studies.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To review and discuss studies on psoriasis vulgaris and HLA, in Caucasian and non\u2010Caucasian populations.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> The major population studies on psoriasis vulgaris and the associated HLA antigens and alleles are described and discussed based on a review of the current literature.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Population studies demonstrate the presence of different HLA specificities as well as extended haplotypes in patients with psoriasis, when compared to controls. Some alleles occur in a lower frequency in patients with psoriasis, indicating they could be protection alleles. In all studies which HLA class I was typed, Cw6 or Cw*0602 was present in a significant frequency in patients with psoriasis, mainly when early onset and positive family history were considered. HLA\u2010DRB1*0701 was also present in a higher frequency in patients in different populations.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Different antigens and alleles from both HLA classes I and II were seen in a significantly higher frequency in patients with psoriasis vulgaris. HLA Cw*0602 and DRB1*0701 were represented in different reports, and the former was related mainly to psoriasis type I.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.02008.x","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T21:04:32Z","timestamp":1170450272000},"page":"303-310","source":"Crossref","is-referenced-by-count":14,"title":["Psoriasis vulgaris and human leukocyte 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