{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:20:20Z","timestamp":1761708020760},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,12]],"date-time":"2007-02-12T00:00:00Z","timestamp":1171238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Although phototherapeutic modalities are commonly used for the treatment of skin diseases, the effects of therapeutic ultraviolet (UV) irradiation on the dermoscopic appearance of melanocytic naevi are unknown.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> We aimed to analyse the effects of photochemotherapy (psoralen plus ultraviolet A, PUVA) and narrow\u2010band ultraviolet B phototherapy (NB\u2010UVB) on the dermoscopic appearance of naevi.<\/jats:p><jats:p><jats:bold>Patients and methods\u2002<\/jats:bold> We monitored 187 melanocytic naevi of 38 patients receiving NB\u2010UVB or PUVA treatment for miscellaneous skin diseases. Dermoscopic images of naevi were taken before, shortly after, and after a median of 31\u00a0weeks after the UV therapy. A random selection of naevi was covered during UV treatment, the others remained uncovered. Baseline and follow\u2010up images of naevi were viewed side by side on a computer screen to compare size, pigmentation, and dermoscopic structure of naevi.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Twenty\u2010one patients received NB\u2010UVB treatment, and 17 patients received PUVA treatment. Of 187 naevi, 70 (37%) were covered and 117 (63%) were uncovered during UV treatment. When NB\u2010UVB\u2010 and PUVA\u2010treated patients were analysed together, an increase in size of uncovered lesions was seen in both treatment groups. Pigmentation appeared darker at the end of UV treatment in 67.5% (<jats:italic>n<\/jats:italic>\u00a0=\u00a079) of uncovered naevi compared with 41.4% (<jats:italic>n<\/jats:italic>\u00a0=\u00a029) of covered naevi (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.001). In patients receiving NB\u2010UVB therapy, a significant increase in the number of dots or globules in 20.3% (<jats:italic>n<\/jats:italic>\u00a0=\u00a014) of uncovered naevi compared with only 5.0% (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) of covered naevi (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.03) was found. This effect was not observed after PUVA therapy. With the exception of four naevi with continuous enlargement and seven naevi with a persisting increase in dots and globules, the observed changes were reversible. All naevi with persistent changes belonged to the NB\u2010UVB group.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> In general, PUVA and NB\u2010UVB therapy cause reversible dermoscopic changes in melanocytic naevi. Increase in dots and globules is more frequent with NB\u2010UVB.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.02020.x","type":"journal-article","created":{"date-parts":[[2007,2,12]],"date-time":"2007-02-12T09:48:12Z","timestamp":1171273692000},"page":"526-531","source":"Crossref","is-referenced-by-count":14,"title":["Changes in the dermoscopic appearance of melanocytic naevi after photochemotherapy or narrow\u2010band ultraviolet B phototherapy"],"prefix":"10.1111","volume":"21","author":[{"given":"I","family":"Kilinc Karaarslan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Teban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Dawid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Tanew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Kittler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12605910"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199502000-00001"},{"key":"e_1_2_5_4_2","first-page":"1412","article-title":"Effect of PUVA and SUP therapy on nevocellular nevi","volume":"56","author":"Pullmann H","year":"1981","journal-title":"Z Hautkr"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2340\/0001555562714","article-title":"The influence of PUVA treatment on the substructure of nevocellular nevi in psoriatic patients","volume":"62","author":"Lagerholm B","year":"1982","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1979.tb05623.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890440049008"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70171-3"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.7.845"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.137.12.1590"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70239-4"},{"key":"e_1_2_5_12_2","first-page":"433","article-title":"Improvement of the diagnostic accuracy in pigmented skin lesions by epiluminescent light microscopy","volume":"7","author":"Steiner A","year":"1987","journal-title":"Anticancer Res"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000412090"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202X.2004.22239.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.2.155"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2006.02020.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2006.02020.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T23:38:38Z","timestamp":1696981118000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2006.02020.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,5]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1111\/j.1468-3083.2006.02020.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2006.02020.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,5]]}}}