{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:48:38Z","timestamp":1789152518431,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,2,6]],"date-time":"2007-02-06T00:00:00Z","timestamp":1170720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Acne is a chronic inflammatory disease of the pilosebaceous follicles. Recent studies bring us increasing evidences that hereditary factors play an important but indirect role in acne.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To investigate the possible role of genetic factors in the pathogenesis of acne vulgaris in Chinese Han ethnic group.<\/jats:p><jats:p><jats:bold>Parients and methods\u2002<\/jats:bold> Volunteers of 975 acne cases and 580 controls were included, contributing 3009 and 1825 first\u2010degree relatives, respectively. One thousand and eighty\u2010five first\u2010degree relatives of acne cases were affected with facial acne. This compared with 223 first\u2010degree relatives of non\u2010acne controls. The odds ratio was used to estimate the relative risk for acne vulgaris associated with having an affected first\u2010degree relative.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The risk of acne vulgaris occurring in a relative of a patient with acne vulgaris was significantly greater than for the relative of an unaffected individual (odds ratio 4.05, 95% confidence interval (CI): 3.45\u20134.76, <jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.001).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Our study suggests that familial factors are important in determining individual susceptibility to acne vulgaris.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.02022.x","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T01:29:36Z","timestamp":1170811776000},"page":"602-605","source":"Crossref","is-referenced-by-count":34,"title":["The familial risk of acne vulgaris in Chinese Hans \u2013 a case\u2010control 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