{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:50:24Z","timestamp":1789775424110,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,1,9]],"date-time":"2007-01-09T00:00:00Z","timestamp":1168300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Quinolone\u2010resistant <jats:italic>Neisseria gonorrhoeae<\/jats:italic> (QRNG) rates are increasing worldwide.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> (i) To assess the rate of QRNG among patients referred to a venereology clinic in Paris between 2000 and 2004; and (ii) to assess associated epidemiological factors.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Retrospective study of consecutive cases over 2000\u20132004. Indications and techniques of swabbing and culture were constant over 2000\u20132004. Susceptibility of <jats:italic>N. gonorrhoeae<\/jats:italic> was tested to six antibiotics: ciprofloxacin, amoxicillin, cefotaxime, tetracycline, erythromycin, and spectinomycin. Epidemiological data and anatomical site of <jats:italic>N. gonorrhoeae<\/jats:italic> infection were collected.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Annual numbers of cases decreased (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a010<jats:sup>\u22124<\/jats:sup>) from 2000 (<jats:italic>n<\/jats:italic>\u00a0=\u00a041) to 2002 (<jats:italic>n<\/jats:italic>\u00a0=\u00a012), then increased (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a010<jats:sup>\u22124<\/jats:sup>) in 2004 (<jats:italic>n<\/jats:italic>\u00a0=\u00a060). Anorectal gonorrhoea was more frequent in 2003\u20132004 (22.0%, <jats:italic>n<\/jats:italic>\u00a0=\u00a018\/82) than in 2000\u20132002 (3.9%, <jats:italic>n<\/jats:italic>\u00a0=\u00a03\/76). QRNG rates increased from the period 2000\u20132002 (1.3%) to 2003 (22.7%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), and 2004 (30.2%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.005). All QRNG strains had a minimal inhibitory concentration of ciprofloxacin &gt;\u00a01.0\u00a0mg\/L, thus fitting the international definition of quinolone resistance. There were no significant changes in rates of <jats:italic>N. gonorrhoeae<\/jats:italic> resistance to the five other antibiotics. QRNG tended to be more frequent among men who have sex with men (MSM; 16.7% vs. 7.1%), HIV\u2010infected patient (20.5% vs. 11.9%), and patients having more than five partners during the last year (24.4% vs. 17.1%), but statistical significance was not reached in multivariate analyses.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> We recommend (i) avoiding fluoroquinolones as first\u2010line treatment for <jats:italic>N. gonorrhoeae<\/jats:italic> infections in Paris; (ii) that first\u2010line treatment relies on third\u2010generation cephalosporins or spectinomycin; and (iii) reinforcing targeted screening and prevention of gonorrhoea, especially among HIV\u2010positive patients and MSM.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.02054.x","type":"journal-article","created":{"date-parts":[[2007,1,9]],"date-time":"2007-01-09T22:22:34Z","timestamp":1168381354000},"page":"818-821","source":"Crossref","is-referenced-by-count":10,"title":["Increasing rates of quinolone\u2010resistant <i>Neisseria gonorrhoeae<\/i> in Paris, France"],"prefix":"10.1111","volume":"21","author":[{"given":"D","family":"Farhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Gerhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Falissard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Poupet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Poyart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Dupin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6,12]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp048126"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000180456.15861.92"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000149848.03733.c1"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2807\/esm.09.12.00491-en","article-title":"A multilevel approach to understanding the resurgence and evolution of infectious syphilis in Western Europe","volume":"9","author":"Fenton KA","year":"2004","journal-title":"Euro Surveill"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2005.03.011"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15543-8"},{"key":"e_1_2_5_8_2","first-page":"1747","article-title":"Une \u00e9pid\u00e9mie de maladie de Nicolas Favre (lymphogranulomatose v\u00e9n\u00e9rienne) en Europe Occidentale","volume":"55","author":"Farhi D","year":"2005","journal-title":"Rev Prat"},{"key":"e_1_2_5_9_2","first-page":"985","article-title":"Lymphogranuloma venereum among men who have sex with men \u2013 Netherlands, 2003\u201304","volume":"53","author":"Centers for Disease Control and Prevention.","year":"2004","journal-title":"MMWR Morb Mortal Wkly Report"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/423966"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000145846.45781.a4"},{"key":"e_1_2_5_12_2","volume-title":"The Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) Year 2004 Report","author":"GRASP Steering Group.","year":"2005"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/432801"},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1128\/AAC.42.11.2919","article-title":"Drift in susceptibility of Neisseria gonorrhoeae to ciprofloxacin and emergence of therapeutic failure","volume":"42","author":"Ison CA","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_2_5_15_2","unstructured":"SoussyCJand the CASFM group.Communiqu\u00e9 2005 Du Comit\u00e9 de l\u2019Antibiogramme de la Soci\u00e9t\u00e9 Fran\u00e7aise de Microbiologie. Soci\u00e9t\u00e9 Fran\u00e7aise de Microbiologie France.http:\/\/www.sfm.asso.fr\/nouv\/general.php?pa=5(last accessed: 8 December 2006)."},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000187197.85419.f8"},{"key":"e_1_2_5_17_2","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines 2002","volume":"51","author":"Centers for Disease Control and Prevention.","year":"2002","journal-title":"MMWR Recomm Report"},{"key":"e_1_2_5_18_2","first-page":"335","article-title":"Increases in fluoroquinolone\u2010resistant Neisseria gonorrhoeae among men who have sex with men \u2013 United States, 2003, and revised recommendations for gonorrhea treatment, 2004","volume":"53","author":"Centers for Disease Control and Prevention.","year":"2004","journal-title":"MMWR Morb Mortal Wkly Report"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2006.02054.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2006.02054.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T16:43:32Z","timestamp":1696956212000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2006.02054.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,12]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["10.1111\/j.1468-3083.2006.02054.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2006.02054.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,12]]}}}