{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:37:55Z","timestamp":1760981875684},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,2,6]],"date-time":"2007-02-06T00:00:00Z","timestamp":1170720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,7]]},"abstract":"Abstract<\/jats:title>Background and objective\u2002<\/jats:bold> Lymphatic mapping\/sentinel lymph node biopsy (LM\/SLNB) have become routine techniques for staging the regional lymph nodes in early stage melanoma, yet their role in the management of thick (=\u00a04\u00a0mm) melanoma is debated. The aim of the present study is to review our experience with LM\/SLNB in a series of patients with thick primary melanoma, to evaluate its utility in this melanoma subset.<\/jats:p>Patients and methods\u2002<\/jats:bold> Thirty patients (18 men and 12 women; mean age 70.6\u00a0years; median 75\u00a0years) with thick primary melanoma underwent LM\/SLNB, using both radioisotope and blue dye. The statistical tests were performed by using SAS software for Windows, version 8.2.<\/jats:p>Results\u2002<\/jats:bold> The primary tumour sites were head\/neck (n<\/jats:italic>\u00a0=\u00a05; 16.6%), trunk (n<\/jats:italic>\u00a0=\u00a010; 33.3%), and extremities (n<\/jats:italic>\u00a0=\u00a015; 50%). Tumour thickness ranged from 4 to 17\u00a0mm (mean 5.14\u00a0mm; median 4.5\u00a0mm). Ulceration was observed in 23 (76.6%) tumours. Eleven patients (36.6%) had at least a positive sentinel lymph node (SLN). The mean follow\u2010up was 27.3\u00a0months (median 26\u00a0months; range 5\u201363\u00a0months). Patients without SLN metastases had a 5\u2010year disease\u2010free survival rate of 78.9%, vs. 18.2% for patients with SLN metastases (P\u00a0=<\/jats:italic>\u00a00.0121 by log rank test). The 5\u2010year overall survival rate for patients without SLN metastases was 89.5%, whereas patients with SLN metastases had a 5\u2010year overall survival rate of 36.4% (P\u00a0=<\/jats:italic>\u00a00.0272 by log rank test).<\/jats:p>Conclusion\u2002<\/jats:bold> Our retrospective analysis indicates that the SLN status is predictive of recurrence and survival in patients with thick melanoma, and LM\/SLNB should be routinely performed in this subset of melanoma patients.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.02072.x","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T01:29:36Z","timestamp":1170811776000},"page":"758-761","source":"Crossref","is-referenced-by-count":18,"title":["Sentinel lymph node biopsy in patients with thick (=\u00a04\u00a0mm) melanoma: a single\u2010centre experience"],"prefix":"10.1111","volume":"21","author":[{"given":"R","family":"Cecchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Buralli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Innocenti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Seghieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"De Gaudio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,12]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.09.029"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06133.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)02136-4"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0011-3840(94)90025-6"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(98)00296-8"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-000-0160-4"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02574492"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02574479"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.03.055"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/000313480407000114","article-title":"Role of sentinel lymph node biopsy in patients with thick (> 4mm) primary melanoma","volume":"70","author":"Jacobs IA","year":"2004","journal-title":"Am Surg"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02574497"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2006.02072.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2006.02072.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T16:42:25Z","timestamp":1696956145000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2006.02072.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,12]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["10.1111\/j.1468-3083.2006.02072.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2006.02072.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,12]]}}}