{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:33:54Z","timestamp":1782124434437,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,2,6]],"date-time":"2007-02-06T00:00:00Z","timestamp":1170720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The mainstay of treatment for pemphigus is systemic corticosteroids. Different adjuvants have been used to reduce side\u2010effects of long\u2010term corticotherapy. Gold is an anti\u2010inflammatory drug used in autoimmune diseases, whose use has waned with the advent of new immunosuppressive agents.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To study the outcome of the use of intramuscular gold treatment of pemphigus vulgaris refractory to previous therapies.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Thirteen patients with pemphigus vulgaris who had failed to respond to several prior therapies were treated with aurothiomalate, as a steroid\u2010sparing agent. Patients were monitored to assess disease activity and gold toxicity.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Seven patients achieved complete remission. Four patients were able to taper prednisone doses, although pemphigus flared when prednisone was discontinued or reduced. Toxicity was observed in the other two patients.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> In 53.4% of the patients, the use of chrysotherapy resulted in the complete clearing of the disease, discontinuation of all systemic therapies and induced a long\u2010term clinical remission. Prednisone doses were able to be reduced in the remaining 46.6%. Any side\u2010effects were reversible with drug discontinuation. Gold therapy showed efficacy as a secondary line treatment in refractory pemphigus vulgaris.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.02074.x","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T01:29:36Z","timestamp":1170811776000},"page":"902-907","source":"Crossref","is-referenced-by-count":11,"title":["Gold: an old drug still working in refractory pemphigus"],"prefix":"10.1111","volume":"21","author":[{"given":"P","family":"Iranzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MaM","family":"Alsina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Mart\u00ednez\u2010De Pablo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Segura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JM","family":"Mascar\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Herrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.1.57"},{"key":"e_1_2_5_3_2","first-page":"926","article-title":"Guidelines for the management of pemphigus vulgaris","volume":"149","author":"Hartman KE","year":"2003","journal-title":"Br Jdermatol"},{"key":"e_1_2_5_4_2","volume-title":"Modern Dermatology and Syphilology","author":"Becker SW","year":"1947"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1973.01620220028007"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","unstructured":"PenneysNS EaglsteinWH FrostP.Management of pemphigus with gold compounds. 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