{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:35:07Z","timestamp":1782484507913,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,2,12]],"date-time":"2007-02-12T00:00:00Z","timestamp":1171238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002\u2002<\/jats:bold> To study the clinical and histopathological features of familial reactive perforating collagenosis (RPC).<\/jats:p><jats:p><jats:bold>Material and methods\u2002<\/jats:bold> Ten patients, including affected siblings in three, took part in the study. Parental consanguinity was present in one. Histopathological study was performed in all patients.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The eruptions appeared mainly during infancy or early childhood as papules showing a central plug, which subsided within 10\u00a0weeks. Areas commonly affected were the face, extremities and trunk. Rare sites were the scalp, ears and buttocks. One pregnant woman, in whom RPC had first manifested around puberty, had relatively widespread lesions. In those with seasonal variation, recurrences were seen a little more frequently in summer than in winter owing to the longer duration of the former. Histopathology confirmed the diagnosis with follicular involvement in four cases. In two patients whose backs were also affected, the lesions went unnoticed, as they were small and inconspicuous. In addition, the brother of a girl with RPC who claimed to be free of the dermatosis, had facial scars suggestive of RPC in the past.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Familial RPC can remain quiescent for a long period and the inherited defect not only shows extreme variability in expression but also demonstrates that lesions can be few and localized so as to escape notice in individuals and family members presenting with this benign, uncommon and self\u2010subsiding dermatosis. In all patients topical retinoic acid was helpful in early regression. Sunscreens may mitigate the severity of RPC in those whose lesions are precipitated in summer but this needs further evaluation.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.02085.x","type":"journal-article","created":{"date-parts":[[2007,2,12]],"date-time":"2007-02-12T09:48:12Z","timestamp":1171273692000},"page":"766-770","source":"Crossref","is-referenced-by-count":25,"title":["Familial reactive perforating collagenosis: a clinical, histopathological study of 10 cases"],"prefix":"10.1111","volume":"21","author":[{"given":"V","family":"Ramesh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Sood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kubba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Makkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6,12]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1967.01610030055009"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1968.01610100021003"},{"key":"e_1_2_5_4_2","first-page":"597","volume-title":"Physiology and Biochemistry of the Skin.","author":"Pinkus H.","year":"1954"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000251165"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03007.x"},{"key":"e_1_2_5_7_2","first-page":"384","article-title":"Acquired reactive perforating collagenosis triggered by scabies infection","volume":"80","author":"Kurschat P","year":"2000","journal-title":"Acta Dermato-Venereol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1001\/archderm.1970.04000090075012","article-title":"Reactive perforating collagenosis. Experimental production of the lesion","volume":"102","author":"Bovenmyer DA","year":"1970","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1365-4362.1985.tb05578.x","article-title":"Reactive perforating collagenosis","volume":"24","author":"Yuzuk S","year":"1985","journal-title":"Int J Dermatol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1985.tb05465.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1987.tb11997.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1001\/archderm.1989.01670200097018","article-title":"Progress in perforating dermatoses (Editorial)","volume":"125","author":"Patterson JW","year":"1989","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1001\/archderm.1989.01670200050007","article-title":"Acquired perforating dermatosis","volume":"125","author":"Rapini RP","year":"1989","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1986.tb02541.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1996.tb00094.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1974.tb13078.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000249895"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000249433"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1001\/archderm.1970.04000110056011","article-title":"Reactive perforating collagenosis","volume":"102","author":"Weiner AL","year":"1970","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1974.tb13077.x"},{"key":"e_1_2_5_21_2","first-page":"87","article-title":"Successful treatment of reactive perforating collagenosis with tretinoin","volume":"23","author":"Cullen SI","year":"1979","journal-title":"Cutis"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2006.02085.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2006.02085.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T16:43:15Z","timestamp":1696956195000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2006.02085.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,12]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["10.1111\/j.1468-3083.2006.02085.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2006.02085.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,12]]}}}