{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:58:46Z","timestamp":1787014726829,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,1,31]],"date-time":"2007-01-31T00:00:00Z","timestamp":1170201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\u2002<\/jats:bold>\n                    Narrow\u2010band ultraviolet B (NB\u2010UVB) phototherapy and topical tacrolimus are included among the most innovative approaches to vitiligo.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective\u2002<\/jats:bold>\n                    To evaluate the efficacy and tolerability of combined treatment with NB\u2010UVB and topical tacrolimus in vitiligo.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods\u2002<\/jats:bold>\n                    After informed consent, adult patients with chronic (&gt;\u00a01\u2010year duration) stable vitiligo refractory to conventional treatments were enrolled in an open\u2010labelled prospective study. Treatment regimen consists of once\u2010daily application, in the evening, of tacrolimus 0.03% ointment to the lesions of the face, or tacrolimus 0.1% ointment to the vitiligous patches located on other areas. Concomitant NB\u2010UVB phototherapy was performed twice weekly for 16\u00a0weeks.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    Study population included 110 patients (mean age, 42) with a total of 403 lesions. Within the treatment period, variable repigmentation was evident on more than 70% of lesions. Clinical response (repigmentation more than 50%) was observed in 42% of lesions. Response was strictly dependent on the site, being more frequent for face lesions (73%), followed by limbs (68%) and trunk (53.5%). The therapeutic effect on the extremities and genital areas was quite disappointing. Treatment was well tolerated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions\u2002<\/jats:bold>\n                    Our preliminary data suggest that the combination of topical tacrolimus with NB\u2010UVB phototherapy can represent an alternative highly effective approach to refractory vitiligo located on the face, trunk and limbs. Long\u2010term safety data and randomized controlled trials on a large number of patients are required.\n                  <\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.02101.x","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T16:04:32Z","timestamp":1170432272000},"page":"916-920","source":"Crossref","is-referenced-by-count":69,"title":["Narrow\u2010band UVB phototherapy combined with tacrolimus ointment in vitiligo: a review of 110 patients"],"prefix":"10.1111","volume":"21","author":[{"given":"D","family":"Fai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Cassano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GA","family":"Vena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(97)00129-6"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02059.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06456.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003263.pub3"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.114752"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.08.047"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.01837.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01413.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2006.00189.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.126250"},{"key":"e_1_2_5_12_2","first-page":"158","article-title":"Tacrolimus ointment 0.1% produces repigmentation in patients with vitiligo: results of a prospective patient series","volume":"71","author":"Tanghetti EA","year":"2003","journal-title":"Cutis"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.5.581"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.05.036"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565040-00002"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0781.2003.00005.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30058.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.9.1065"},{"key":"e_1_2_5_19_2","first-page":"150","article-title":"A new digital image analysis system useful for surface assessment of vitiligo lesions in transplantation studies","volume":"14","author":"Van Geel N","year":"2004","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.7.927"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.031"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06739.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.2.252"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23858.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000088505"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2003.tb00482.x"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06394.x"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06779.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2006.02101.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2006.02101.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T15:57:34Z","timestamp":1696953454000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2006.02101.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,18]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1111\/j.1468-3083.2006.02101.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2006.02101.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,18]]}}}