{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T10:37:31Z","timestamp":1794220651590,"version":"4.8.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,1,31]],"date-time":"2007-01-31T00:00:00Z","timestamp":1170201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To study the involvement of stress before the onset\/development of alopecia areata and vitiligo.<\/jats:p><jats:p><jats:bold>Patients and method\u2002<\/jats:bold> Forty\u2010five outpatients with alopecia areata and 32 outpatients with vitiligo were enrolled. The design was a case\u2010control study (controls had skin diseases unrelated to stress). Stressful events were evaluated using Holmes and Rahe's social readjustment rating scale.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Mean age was around 30\u00a0years in both conditions. More than 65% of cases (both alopecia areata and vitiligo) experienced stressful events compared to 22% of controls. The odds ratio was 7.75 for alopecia areata and 6.81 for vitiligo. There was a significant difference in the mean number of stressful events between alopecia areata patients and controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005), and also a significant difference in the number of stressful events between men (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.05) and women (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) across these two groups. In the vitiligo group there was a significant difference in the mean number of stressful events between patients and controls only in women (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). A potential stressful situation occurred more often in both patient groups. Alopecia areata patients described family problems in 45.6% of patients (especially women), which was statistically significant when compared to controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0004). Personal problems were reported by 35.7% of alopecia areata patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04 compared to controls). Vitiligo patients mentioned personal problems in 47% of cases (one\u2010third were related to exams) and 31% of cases were related to job\/financial problems. Again, this was statistically significant when compared to controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0002).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Stress seems to play an important role in the onset and aggravation of both alopecia areata and vitiligo, mostly with one stressful event before disease onset.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.02106.x","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T21:04:32Z","timestamp":1170450272000},"page":"921-928","source":"Crossref","is-referenced-by-count":125,"title":["Stress in patients with alopecia areata and vitiligo"],"prefix":"10.1111","volume":"21","author":[{"given":"Liana","family":"Manolache","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasile","family":"Benea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,18]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70368-5"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-440X(91)90045-E"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1994.tb01018.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01340.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2003.tb00341.x"},{"issue":"1","key":"e_1_2_7_7_2","first-page":"299","article-title":"Psychosomatic aspects in alopecia","volume":"16","author":"Manolache L","year":"2002","journal-title":"JEADV"},{"key":"e_1_2_7_8_2","first-page":"112","article-title":"Stress and anxiety involved in alopecia areata","volume":"4","author":"Manolache L","year":"2003","journal-title":"Dermatol Psychosom"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02028.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000017500"},{"issue":"1","key":"e_1_2_7_11_2","first-page":"S19","article-title":"Vitiligo: an under\u2010estimated problem","volume":"15","author":"Agarwal G","year":"1998","journal-title":"Fam Pract"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2002.00590.x"},{"key":"e_1_2_7_13_2","first-page":"107","article-title":"Vitiligo: its personality profile","volume":"4","author":"Elgowieni M","year":"2003","journal-title":"Dermatol Psychosom"},{"issue":"1","key":"e_1_2_7_14_2","first-page":"42","article-title":"Alopecia areata as psychosomatic event. 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