{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:23:30Z","timestamp":1790396610831,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T00:00:00Z","timestamp":1168905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The first choice treatment for vitiligo vulgaris is narrow\u2010band UVB (NB\u2010UVB), but no satisfactory treatment exists.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To investigate if <jats:italic>Polypodium leucotomos<\/jats:italic>, an antioxidative and immunomodulatory plant extract, improves NB\u2010UVB\u2010induced repigmentation.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Fifty patients with vitiligo vulgaris randomly received 250\u00a0mg oral <jats:italic>P. leucotomos<\/jats:italic> or placebo three times daily, combined with NB\u2010UVB twice weekly for 25\u201326\u00a0weeks.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Repigmentation was higher in the <jats:italic>P. leucotomos<\/jats:italic> group vs. placebo in the head and neck area (44% vs. 27%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.06). Small repigmentation increases (<jats:italic>P\u00a0=<\/jats:italic>\u00a0n.s.) were observed for the trunk (6% increased repigmentation), extremities (4%), and hands and feet (5%) in the <jats:italic>P. leucotomos<\/jats:italic> group vs. placebo. Patients attending more than 80% of required NB\u2010UVB sessions showed increased repigmentation in the head and neck area in the <jats:italic>P. leucotomos<\/jats:italic> group vs. placebo (50% vs. 19%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.002); no significant differences were seen in the other body areas. Patients with skin types 2 and 3 showed more repigmentation in the head and neck area in the <jats:italic>P. leucotomos<\/jats:italic> group vs. placebo (47% vs. 21%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01), and no significant differences were seen in the other body areas. No conclusions could be drawn on skin types 4 and 5 due to low patient numbers.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> There is a clear trend towards an increase in repigmentation of vitiligo vulgaris affecting the head and neck area when NB\u2010UVB phototherapy is combined with oral <jats:italic>P. leucotomos<\/jats:italic>. This effect may be more pronounced in light skin types.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2006.02132.x","type":"journal-article","created":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T23:39:40Z","timestamp":1168990780000},"page":"942-950","source":"Crossref","is-referenced-by-count":139,"title":["Treatment of vitiligo vulgaris with narrow\u2010band UVB and oral <i>Polypodium leucotomos<\/i> extract: a randomized double\u2010blind placebo\u2010controlled 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