{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:44:29Z","timestamp":1789533869011,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,6,22]],"date-time":"2007-06-22T00:00:00Z","timestamp":1182470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The therapy of pediculosis remains a common problem in clinical practice. As resistance to commonly used chemical pediculicides is constantly increasing, there is a need for new effective compounds.<\/jats:p><jats:p><jats:bold>Study design\u2002<\/jats:bold> The efficacy of Nyda\u00ae L, a new pediculicide containing a high concentration of dimeticone, was assessed in an <jats:italic>in vitro<\/jats:italic> trial and compared with three reference products (Hedrin\u00ae containing 4% dimeticone, Lyclear\u00ae containing 1% permethrin, and Prioderm\u00ae containing 1% malathion) and a negative control group. Head lice were collected from heavily infested patients in a resource\u2010poor community in Northeast Brazil, where no resistance against pediculicides has been reported thus far. In each of the five groups, 50 adult fully vital lice were tested. We used a dip test (immersing head lice in the undiluted products for 3 min, washing off products after 20\u00a0min). Using predefined criteria for mortality, the lice were monitored at different points in time, for a period of 24\u00a0h.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Nyda\u00ae L and Prioderm\u00ae killed all head lice already after 5\u00a0min. The efficacy of Nyda\u00ae L was better than of Lyclear\u00ae. Lice treated with Hedrin\u00ae resurrected after several hours and did not show a significantly higher mortality compared with the control group after 24\u00a0h.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Nyda\u00ae L can be regarded as a very efficacious pediculicidal compound, killing all lice <jats:italic>in vitro<\/jats:italic> within 5 min.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2007.02258.x","type":"journal-article","created":{"date-parts":[[2007,6,22]],"date-time":"2007-06-22T20:01:49Z","timestamp":1182542509000},"page":"1325-1329","source":"Crossref","is-referenced-by-count":29,"title":["High <i>in vitro<\/i> efficacy of Nyda<sup>\u00ae<\/sup> L, a pediculicide containing 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