{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:11:34Z","timestamp":1790172694936,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,6,22]],"date-time":"2007-06-22T00:00:00Z","timestamp":1182470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Prevalence of clinically manifest orofacial herpes in the general population is poorly characterized.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To establish the lifetime prevalence of clinically manifest orofacial herpes and its relationship with herpes simplex virus (HSV) serotype in the French general population.<\/jats:p><jats:p><jats:bold>Patients\/methods\u2002<\/jats:bold> Subjects (<jats:italic>N<\/jats:italic>\u00a0= 2796) were serotyped for HSV1 and HSV2 and provided data on herpetic symptoms by questionnaire. Subjects reporting at least one episode of orobuccal ulcerative mucosal lesions were classified as clinically manifest orofacial herpes.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Lifetime prevalence of clinically manifest orofacial herpes was 38.3% (42.1% in women, 32.4% in men). Prevalence in subjects seropositive for HSV1 was 50.3%. This prevalence rate was independent of HSV2 serotype. Prevalence in subjects infected with HSV2 alone was similar to that in subjects seronegative for HSV.<\/jats:p><jats:p><jats:bold>Limitations\u2002<\/jats:bold> Lack of case ascertainment limits precision of the data.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Clinically manifest orofacial herpes was reported in one third of the sample, principally associated with HSV1 infection. HSV2 infection did not produce orofacial lesions nor influence clinical manifestations of HSV1 infection.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2007.02302.x","type":"journal-article","created":{"date-parts":[[2007,6,22]],"date-time":"2007-06-22T20:01:49Z","timestamp":1182542509000},"page":"1398-1403","source":"Crossref","is-referenced-by-count":21,"title":["Epidemiology of orofacial herpes simplex virus infections in the general population in France: results of the HERPIMAX study"],"prefix":"10.1111","volume":"21","author":[{"given":"D","family":"Malvy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Ezzedine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Lan\u00e7on","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Halioua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Rezvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bertrais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Chanzy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u2010E","family":"Malkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Morand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"De Labareyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Hercberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"El Hasnaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6,22]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"19","article-title":"Sero\u2010epidemiological and \u2010sociological patterns of herpes simplex virus infection in the world","volume":"69","author":"Nahmias AJ","year":"1990","journal-title":"Scand J Infect Dis Suppl"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/26.4.698"},{"key":"e_1_2_5_4_2","first-page":"177","article-title":"Epidemiology of genital herpes \u2013 recent advances","volume":"9","author":"Halioua B","year":"1999","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_5_2","first-page":"51","article-title":"The changing epidemiology of HSV\u20101 and HSV\u20102 and implications for serological testing","volume":"9","author":"Lafferty WE","year":"2002","journal-title":"Herpes"},{"issue":"1","key":"e_1_2_5_6_2","first-page":"2A","article-title":"Epidemiology of genital herpes simplex virus infection in developed countries","volume":"11","author":"Malkin JE","year":"2004","journal-title":"Herpes"},{"key":"e_1_2_5_7_2","first-page":"8","article-title":"Genital herpes in Europe","volume":"16","author":"Patel R.","year":"2002","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_2_5_8_2","first-page":"67","volume-title":"The Human Herpesviruses","author":"Whitley RJ","year":"1993"},{"key":"e_1_2_5_9_2","first-page":"627","article-title":"Prevalence of recurrent herpes labialis and aphthous ulcers among young adults on six continents","volume":"113","author":"Embil JA","year":"1975","journal-title":"Can Med Assoc J"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114837"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2004.00157.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2005.00632.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1994.tb01815.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.10.014"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.290707.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199710163371601"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/343739"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.21.2335"},{"key":"e_1_2_5_19_2","first-page":"3","article-title":"Background and rationale behind the SU.VI.MAX Study, a prevention trial using nutritional doses of a combination of antioxidant vitamins and minerals to reduce cardiovascular diseases and cancers. 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